Epipen and Pre-eclampsia aggravated - a phase IV clinical study of FDA data

Summary:

Pre-eclampsia aggravated is reported as a side effect among people who take Epipen (epinephrine), especially for people who are 30-39 old, also take Xyrem, and have Cataplexy.

The phase IV clinical study analyzes which people have Pre-eclampsia aggravated when taking Epipen. It is created by eHealthMe based on reports of 23,690 people who have side effects when taking Epipen from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Pre-eclampsia aggravated?

Pre-eclampsia aggravated (serious high blood pressure and significant amounts of protein in the urine of a pregnant woman) is found to be associated with 379 drugs and 284 conditions by eHealthMe. Check the latest studies of Pre-eclampsia aggravated.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

23,690 people reported to have side effects when taking Epipen.
Among them, 12 people (0.05%) have Pre-eclampsia aggravated.

Could Epipen cause Pre-eclampsia aggravated?

Among these 12 people:

What is the age of people who have Pre-eclampsia aggravated when taking Epipen? *

What are other drugs people take besides Epipen? *

What are other side effects people have besides Pre-eclampsia aggravated? *

Premature Delivery: 4 people, 33.33%
High Blood Pressure: 4 people, 33.33%
Asthma: 4 people, 33.33%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 33.33%
Maternal Exposure Before Pregnancy (use of substance before pregnancy): 3 people, 25.00%
Hypotension (abnormally low blood pressure): 2 people, 16.67%
Gestational Diabetes (diabetes in pregnancy): 2 people, 16.67%
Cardiolipin Antibody Positive: 1 person, 8.33%
Cervical Dysplasia (abnormal changes in the cells on the surface of the cervix): 1 person, 8.33%
Fatigue (feeling of tiredness): 1 person, 8.33%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 50.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 50.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 2 people, 16.67%
Birth Control: 2 people, 16.67%
Urticaria (rash of round, red welts on the skin that itch intensely): 1 person, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 8.33%
Nausea (feeling of having an urge to vomit): 1 person, 8.33%
Immunodeficiency Disorders: 1 person, 8.33%
Immunodeficiency Common Variable: 1 person, 8.33%
Idiopathic Urticaria (allergic reactions, presence of hives with unknown cause): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Epipen and have Pre-eclampsia aggravated?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epipen:

Epipen (23,760 reports)

Browse all side effects of Epipen:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pre-eclampsia aggravated:

Pre-eclampsia aggravated (379 drugs)

Browse all the conditions that are associated with Pre-eclampsia aggravated:

Pre-eclampsia aggravated (284 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine (the active ingredients of Epipen) and Epipen (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.