Epo and Fatigue - a phase IV clinical study of FDA data

Summary:

Fatigue is reported as a side effect among people who take Epo (evening primrose oil), especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months also take Exjade, and have Hypothyroidism.

The phase IV clinical study analyzes which people have Fatigue when taking Epo. It is created by eHealthMe based on reports of 232 people who have side effects when taking Epo from the FDA, and is updated regularly.

What is Epo?

Epo has active ingredients of evening primrose oil. eHealthMe is studying from 254 Epo users. Check the latest studies of Epo.

What is Fatigue?

Fatigue (feeling of tiredness) is found to be associated with 4,026 drugs and 6,380 conditions by eHealthMe. Check the latest studies of Fatigue.

On Jul, 24, 2026

232 people reported to have side effects when taking Epo.
Among them, 13 people (5.6%) have Fatigue.

Among these 13 people:

How long have people been on Epo when they have Fatigue? *

What is the gender of people who have Fatigue when taking Epo? *

female: 50 %
male: 50 %

What is the age of people who have Fatigue when taking Epo? *

What are other drugs people take besides Epo? *

What are other side effects people have besides Fatigue? *

Dyspnea (difficult or laboured breathing): 6 people, 46.15%
Weakness: 6 people, 46.15%
Serum Ferritin Increased: 6 people, 46.15%
Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 5 people, 38.46%
Blood Iron Increased: 5 people, 38.46%
Red Blood Cell Count Decreased: 5 people, 38.46%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 38.46%
White Blood Cell Count Decreased: 5 people, 38.46%
Haemoglobin Decreased: 5 people, 38.46%
Haematocrit Decreased: 5 people, 38.46%

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 5 people, 38.46%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 38.46%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 38.46%
Iron Overload: 2 people, 15.38%
Urinary Tract Infection: 1 person, 7.69%
Type 2 Diabetes: 1 person, 7.69%
Myelodysplastic Syndrome (a group of conditions that occur when the blood-forming cells in the bone marrow are damaged): 1 person, 7.69%
Multiple Myeloma (cancer of the plasma cells): 1 person, 7.69%
High Blood Pressure: 1 person, 7.69%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Epo and have Fatigue?

- Check whether Fatigue is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Epo:

Epo (254 reports)

Fatigue treatments and more:

Fatigue (967,537 reports)

Browse all side effects of Epo:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Fatigue:

Fatigue (4,026 drugs)

Browse all the conditions that are associated with Fatigue:

Fatigue (6,380 conditions)

Related publications that referenced our studies

Min IS, Lee JY, Jung TS, Kang NK, Park BB, Kim BK, "Development of a Complete Atrioventricular Block Associated with Intake of Evening Primrose Oil", The Korean Journal of Medicine, 2016 May .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .
Min IS, Lee JY, Jung TS, Kang NK, Park BB, Kim BK, "Development of a Complete Atrioventricular Block Associated with Intake of Evening Primrose Oil", The Korean Journal of Medicine, 2016 May .
Peel MM, Cooke M, Lewis-Peel HJ, Lea RA, Moyle W, "A randomized controlled trial of coenzyme Q 10 for fatigue in the late-onset sequelae of poliomyelitis", Complementary therapies in medicine, 2015 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on evening primrose oil (the active ingredients of Epo) and Epo (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.