Esgic-plus and Pain - a phase IV clinical study of FDA data

Summary:

Pain is reported as a side effect among people who take Esgic-plus (acetaminophen; butalbital; caffeine), especially for people who are female, 30-39 old, have been taking the drug for 5 - 10 years also take Xanax, and have Depression.

The phase IV clinical study analyzes which people have Pain when taking Esgic-plus. It is created by eHealthMe based on reports of 239 people who have side effects when taking Esgic-plus from the FDA, and is updated regularly.

What is Esgic-plus?

Esgic-plus has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 269 Esgic-plus users. Check the latest studies of Esgic-plus.

What is Pain?

Pain is found to be associated with 3,809 drugs and 5,870 conditions by eHealthMe. Check the latest studies of Pain.

On Aug, 08, 2026

239 people reported to have side effects when taking Esgic-plus.
Among them, 21 people (8.79%) have Pain.

Among these 21 people:

How long have people been on Esgic-plus when they have Pain? *

What is the gender of people who have Pain when taking Esgic-plus? *

female: 95 %
male: 5 %

What is the age of people who have Pain when taking Esgic-plus? *

What are other drugs people take besides Esgic-plus? *

What are other side effects people have besides Pain? *

Depression: 5 people, 23.81%
Emotional Distress: 5 people, 23.81%
Nausea And Vomiting: 4 people, 19.05%
Drug Dependence: 4 people, 19.05%
Drug Ineffective: 4 people, 19.05%
Nausea (feeling of having an urge to vomit): 4 people, 19.05%
High Blood Pressure: 4 people, 19.05%
Abdominal Pain: 4 people, 19.05%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 3 people, 14.29%
Weight Decreased: 3 people, 14.29%

What are the existing conditions these people have? *

Depression: 6 people, 28.57%
Acne (skin problems that cause pimples): 5 people, 23.81%
Headache (pain in head): 4 people, 19.05%
Birth Control: 4 people, 19.05%
Asthma: 3 people, 14.29%
Cardiac Disorder: 3 people, 14.29%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 3 people, 14.29%
Stress And Anxiety: 3 people, 14.29%
High Blood Pressure: 3 people, 14.29%
Post-Traumatic Stress Disorder: 3 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Esgic-plus and have Pain?

- Check whether Pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Esgic-plus:

Esgic-plus (269 reports)

Pain treatments and more:

Pain (1,140,595 reports)

How severe was Pain and when was it recovered:

Pain in Esgic-plus

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Pain and drugs with ingredients of acetaminophen; butalbital; caffeine (5,084 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Esgic-plus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pain:

Pain (3,809 drugs)

Browse all the conditions that are associated with Pain:

Pain (5,870 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Esgic-plus) and Esgic-plus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.