Esgic and Head injury - a phase IV clinical study of FDA data

Summary:

Head injury is reported as a side effect among people who take Esgic (acetaminophen; butalbital; caffeine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Xyrem, and have Narcolepsy.

The phase IV clinical study analyzes which people have Head injury when taking Esgic. It is created by eHealthMe based on reports of 813 people who have side effects when taking Esgic from the FDA, and is updated regularly.

What is Esgic?

Esgic has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 882 Esgic users. Check the latest studies of Esgic.

What is Head injury?

Head injury is found to be associated with 2,628 drugs and 3,247 conditions by eHealthMe. Check the latest studies of Head injury.

On Jul, 13, 2026

813 people reported to have side effects when taking Esgic.
Among them, 18 people (2.21%) have Head injury.

Among these 18 people:

How long have people been on Esgic when they have Head injury? *

What is the gender of people who have Head injury when taking Esgic? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Head injury when taking Esgic? *

What are other drugs people take besides Esgic? *

What are other side effects people have besides Head injury? *

Fall: 6 people, 33.33%
Malaise (a feeling of general discomfort or uneasiness): 5 people, 27.78%
Fatigue (feeling of tiredness): 5 people, 27.78%
Nausea And Vomiting: 4 people, 22.22%
Sinusitis (inflammation of sinus): 3 people, 16.67%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 3 people, 16.67%
Haemorrhage (bleeding): 3 people, 16.67%
Weight Fluctuation: 3 people, 16.67%
Depression: 3 people, 16.67%
Nasopharyngitis (inflammation of the nasopharynx): 3 people, 16.67%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 33.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 16.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 16.67%
High Blood Pressure: 2 people, 11.11%
Osteoporosis (bones weak and more likely to break): 2 people, 11.11%
Immunodeficiency Common Variable: 2 people, 11.11%
Insomnia (sleeplessness): 1 person, 5.56%
Basedow's Disease (autoimmune disease where the thyroid is overactive, producing an excessive amount of thyroid hormones): 1 person, 5.56%
Colitis (inflammation of colon): 1 person, 5.56%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Esgic and have Head injury?

- Check whether Head injury is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Esgic:

Esgic (882 reports)

Head injury treatments and more:

Head injury (160,560 reports)

How severe was Head injury and when was it recovered:

Head injury in Esgic

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Head injury and drugs with ingredients of acetaminophen; butalbital; caffeine (1,236 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Esgic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Head injury:

Head injury (2,628 drugs)

Browse all the conditions that are associated with Head injury:

Head injury (3,247 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Esgic) and Esgic (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.