1. Home
  2. Analysis
  3. Estrace
  4. Intervertebral-disc-protrusion

Estrace and Intervertebral disc protrusion - a phase IV clinical study of FDA data

Summary:

Intervertebral disc protrusion is reported as a side effect among people who take Estrace (estradiol), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Synthroid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Intervertebral disc protrusion when taking Estrace. It is created by eHealthMe based on reports of 16,282 people who have side effects when taking Estrace from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Intervertebral disc protrusion?

Intervertebral disc protrusion (spinal disc protrusion) is found to be associated with 1,531 drugs and 1,306 conditions by eHealthMe. Check the latest studies of Intervertebral disc protrusion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

16,282 people reported to have side effects when taking Estrace.
Among them, 82 people (0.5%) have Intervertebral disc protrusion.

Could Estrace cause Intervertebral disc protrusion?

Among these 82 people:

How long have people been on Estrace when they have Intervertebral disc protrusion? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 80 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 20 %

What is the gender of people who have Intervertebral disc protrusion when taking Estrace? *

  • female: 97.5 %
  • male: 2.5 %

What is the age of people who have Intervertebral disc protrusion when taking Estrace? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 3.23 %
  • 40-49: 8.06 %
  • 50-59: 32.26 %
  • 60+: 56.45 %

What are other drugs people take besides Estrace? *

  1. Synthroid: 31 people, 37.80%
  2. Prilosec: 17 people, 20.73%
  3. Zanaflex: 17 people, 20.73%
  4. Ambien: 15 people, 18.29%
  5. Miacalcin: 15 people, 18.29%
  6. Aspirin: 15 people, 18.29%
  7. Clonazepam: 15 people, 18.29%
  8. Lasix: 15 people, 18.29%
  9. Folic Acid: 15 people, 18.29%
  10. Neurontin: 14 people, 17.07%

What are other side effects people have besides Intervertebral disc protrusion? *

  1. Spinal Osteoarthritis (joint cartilage loss in spine): 29 people, 35.37%
  2. Urinary Tract Infection: 28 people, 34.15%
  3. Fall: 27 people, 32.93%
  4. Stress And Anxiety: 24 people, 29.27%
  5. Depression: 24 people, 29.27%
  6. High Blood Pressure: 23 people, 28.05%
  7. Pain: 23 people, 28.05%
  8. Intervertebral Disc Degeneration (spinal disc degeneration): 21 people, 25.61%
  9. Osteoarthritis (a joint disease caused by cartilage loss in a joint): 19 people, 23.17%
  10. Fatigue (feeling of tiredness): 18 people, 21.95%

What are the existing conditions these people have? *

  1. Osteopenia (a condition where bone mineral density is lower than normal): 11 people, 13.41%
  2. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 11 people, 13.41%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 9.76%
  4. Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 7 people, 8.54%
  5. Postmenopause: 5 people, 6.10%
  6. Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 5 people, 6.10%
  7. Seasonal Allergy (allergic condition due to certain season): 5 people, 6.10%
  8. Immunodeficiency Common Variable: 5 people, 6.10%
  9. Stress And Anxiety: 5 people, 6.10%
  10. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 6.10%

* Approximation only. Some reports may have incomplete information.

Do you take Estrace and have Intervertebral disc protrusion?

- Check whether Intervertebral disc protrusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrace:

Intervertebral disc protrusion treatments and more:

How severe was Intervertebral disc protrusion and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc protrusion:

Browse all the conditions that are associated with Intervertebral disc protrusion:

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.