Estrace and Wheezing - a phase IV clinical study of FDA data

Summary:

Wheezing is reported as a side effect among people who take Estrace (estradiol), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Lipitor, and have Asthma.

The phase IV clinical study analyzes which people have Wheezing when taking Estrace. It is created by eHealthMe based on reports of 16,282 people who have side effects when taking Estrace from the FDA, and is updated regularly.

What is Estrace?

Estrace has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 16,703 Estrace users. Check the latest studies of Estrace.

What is Wheezing?

Wheezing (a high-pitched whistling sound made while you breath) is found to be associated with 1,810 drugs and 2,207 conditions by eHealthMe. Check the latest studies of Wheezing.



On Jul, 21, 2026

16,282 people reported to have side effects when taking Estrace.
Among them, 65 people (0.4%) have Wheezing.

Could Estrace cause Wheezing?

Among these 65 people:

How long have people been on Estrace when they have Wheezing? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 80 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 20 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Wheezing when taking Estrace? *

  • female: 100 %
  • male: 0.0 %

What is the age of people who have Wheezing when taking Estrace? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 5.56 %
  • 50-59: 22.22 %
  • 60+: 72.22 %

What are other drugs people take besides Estrace? *

  1. Lipitor: 18 people, 27.69%
  2. Vitamin B12: 16 people, 24.62%
  3. Ventolin: 15 people, 23.08%
  4. Proair Hfa: 14 people, 21.54%
  5. Symbicort: 13 people, 20.00%
  6. Amlodipine: 12 people, 18.46%
  7. Zantac: 12 people, 18.46%
  8. Vitamin C: 12 people, 18.46%
  9. Spiriva: 11 people, 16.92%
  10. Lasix: 11 people, 16.92%

What are other side effects people have besides Wheezing? *

  1. Cough: 47 people, 72.31%
  2. Dyspnea (difficult or laboured breathing): 23 people, 35.38%
  3. Fatigue (feeling of tiredness): 20 people, 30.77%
  4. Malaise (a feeling of general discomfort or uneasiness): 19 people, 29.23%
  5. Urinary Tract Infection: 19 people, 29.23%
  6. Oropharyngeal Pain: 19 people, 29.23%
  7. Head Injury: 19 people, 29.23%
  8. Pain In Extremity: 18 people, 27.69%
  9. Nasopharyngitis (inflammation of the nasopharynx): 17 people, 26.15%
  10. Nausea (feeling of having an urge to vomit): 17 people, 26.15%

What are the existing conditions these people have? *

  1. Asthma: 17 people, 26.15%
  2. High Blood Pressure: 11 people, 16.92%
  3. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 13.85%
  4. Type 2 Diabetes: 8 people, 12.31%
  5. Hormone Level Abnormal: 8 people, 12.31%
  6. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 8 people, 12.31%
  7. Urinary Tract Infection: 7 people, 10.77%
  8. Osteopenia (a condition where bone mineral density is lower than normal): 6 people, 9.23%
  9. Multiple Myeloma (cancer of the plasma cells): 6 people, 9.23%
  10. Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Estrace and have Wheezing?

- Check whether Wheezing is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously



Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrace:

Wheezing treatments and more:

How severe was Wheezing and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Estrace:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Wheezing:

Browse all the conditions that are associated with Wheezing:


How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrace) and Estrace (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



Recent studies on eHealthMe: