Estraderm and Confusional state - a phase IV clinical study of FDA data

Summary:

Confusional state is reported as a side effect among people who take Estraderm (estradiol), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Premarin, and have Depression.

The phase IV clinical study analyzes which people have Confusional state when taking Estraderm. It is created by eHealthMe based on reports of 3,394 people who have side effects when taking Estraderm from the FDA, and is updated regularly.

What is Estraderm?

Estraderm has active ingredients of estradiol. It is often used in hormone replacement therapy. eHealthMe is studying from 3,441 Estraderm users. Check the latest studies of Estraderm.

What is Confusional state?

Confusional state is found to be associated with 2,718 drugs and 3,320 conditions by eHealthMe. Check the latest studies of Confusional state.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

3,394 people reported to have side effects when taking Estraderm.
Among them, 39 people (1.15%) have Confusional state.

Could Estraderm cause Confusional state?

Among these 39 people:

How long have people been on Estraderm when they have Confusional state? *

What is the gender of people who have Confusional state when taking Estraderm? *

female: 100 %
male: 0.0 %

What is the age of people who have Confusional state when taking Estraderm? *

What are other drugs people take besides Estraderm? *

What are other side effects people have besides Confusional state? *

Fatigue (feeling of tiredness): 15 people, 38.46%
Headache (pain in head): 14 people, 35.90%
Stress And Anxiety: 14 people, 35.90%
Dizziness: 12 people, 30.77%
Nausea (feeling of having an urge to vomit): 10 people, 25.64%
Depression: 10 people, 25.64%
Loss Of Consciousness: 9 people, 23.08%
Anger: 9 people, 23.08%
Mood Swings (an extreme or rapid change in mood): 9 people, 23.08%
Speech Impairment (Adult) (inability to speak (adult)): 9 people, 23.08%

What are the existing conditions these people have? *

Depression: 8 people, 20.51%
Migraine (headache): 5 people, 12.82%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 12.82%
High Blood Pressure: 4 people, 10.26%
High Blood Cholesterol: 4 people, 10.26%
Constipation: 3 people, 7.69%
Diabetes: 3 people, 7.69%
Type 2 Diabetes: 3 people, 7.69%
Hair Loss: 3 people, 7.69%
Glaucoma (increased fluid pressure in the eye with vision loss): 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Estraderm and have Confusional state?

- Check whether Confusional state is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estraderm:

Estraderm (3,441 reports)

Confusional state treatments and more:

Confusional state (182,510 reports)

Browse all side effects of Estraderm:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Confusional state:

Confusional state (2,718 drugs)

Browse all the conditions that are associated with Confusional state:

Confusional state (3,320 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estraderm) and Estraderm (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.