Estradiol valerate and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Estradiol valerate (estradiol valerate), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Acetaminophen, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Headache when taking Estradiol valerate. It is created by eHealthMe based on reports of 315 people who have side effects when taking Estradiol valerate from the FDA, and is updated regularly.

What is Estradiol valerate?

Estradiol valerate has active ingredients of estradiol valerate. eHealthMe is studying from 347 Estradiol valerate users. Check the latest studies of Estradiol valerate.

What is Headache?

Headache (pain in head) is found to be associated with 3,756 drugs and 5,776 conditions by eHealthMe. Check the latest studies of Headache.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

315 people reported to have side effects when taking Estradiol valerate.
Among them, 34 people (10.79%) have Headache.

Could Estradiol valerate cause Headache?

Among these 34 people:

How long have people been on Estradiol valerate when they have Headache? *

What is the gender of people who have Headache when taking Estradiol valerate? *

female: 97.06 %
male: 2.94 %

What is the age of people who have Headache when taking Estradiol valerate? *

What are other drugs people take besides Estradiol valerate? *

Acetaminophen: 21 people, 61.76%
Synthroid: 17 people, 50.00%
Actemra: 15 people, 44.12%
Venlafaxine Hydrochloride: 15 people, 44.12%
Lipitor: 14 people, 41.18%
Xanax: 14 people, 41.18%
Delatestryl: 14 people, 41.18%
Nadolol: 13 people, 38.24%
Apixaban: 12 people, 35.29%
Rosuvastatin Calcium: 9 people, 26.47%

What are other side effects people have besides Headache? *

Fatigue (feeling of tiredness): 26 people, 76.47%
Pain: 18 people, 52.94%
Joint Pain: 18 people, 52.94%
Muscle Aches (muscle pain): 18 people, 52.94%
Weight Increased: 17 people, 50.00%
Fungal Infection: 17 people, 50.00%
Abdominal Pain: 17 people, 50.00%
Weakness: 16 people, 47.06%
Sinusitis (inflammation of sinus): 16 people, 47.06%
Dyspnea (difficult or laboured breathing): 16 people, 47.06%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 44.12%
High Blood Cholesterol: 7 people, 20.59%
Immunodeficiency Common Variable: 3 people, 8.82%
Hair Disorder: 2 people, 5.88%
Affective Disorder (mental disorder): 2 people, 5.88%
Osteoporosis (bones weak and more likely to break): 2 people, 5.88%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 5.88%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 2.94%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 2.94%
Back Pain: 1 person, 2.94%

* Approximation only. Some reports may have incomplete information.

Do you take Estradiol valerate and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estradiol valerate:

Estradiol valerate (347 reports)

Headache treatments and more:

Headache (756,645 reports)

Browse all side effects of Estradiol valerate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,756 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,776 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol valerate (the active ingredients of Estradiol valerate) and Estradiol valerate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.