Estrogel and Abdominal pain - a phase IV clinical study of FDA data

Summary:

Abdominal pain is reported as a side effect among people who take Estrogel (estradiol), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Synthroid, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Abdominal pain when taking Estrogel. It is created by eHealthMe based on reports of 2,659 people who have side effects when taking Estrogel from the FDA, and is updated regularly.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,921 Estrogel users. Check the latest studies of Estrogel.

What is Abdominal pain?

Abdominal pain is found to be associated with 3,226 drugs and 5,745 conditions by eHealthMe. Check the latest studies of Abdominal pain.



On Jul, 20, 2026

2,659 people reported to have side effects when taking Estrogel.
Among them, 66 people (2.48%) have Abdominal pain.

Could Estrogel cause Abdominal pain?

Among these 66 people:

How long have people been on Estrogel when they have Abdominal pain? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Abdominal pain when taking Estrogel? *

  • female: 96.61 %
  • male: 3.39 %

What is the age of people who have Abdominal pain when taking Estrogel? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 8.51 %
  • 40-49: 8.51 %
  • 50-59: 48.94 %
  • 60+: 34.04 %

What are other drugs people take besides Estrogel? *

  1. Synthroid: 11 people, 16.67%
  2. Prometrium: 8 people, 12.12%
  3. Inflectra: 7 people, 10.61%
  4. Ventolin: 6 people, 9.09%
  5. Vitamin B12: 5 people, 7.58%
  6. Actemra: 5 people, 7.58%
  7. Vitamin D: 5 people, 7.58%
  8. Elavil: 5 people, 7.58%
  9. Prednisone: 4 people, 6.06%
  10. Sertraline: 4 people, 6.06%

What are other side effects people have besides Abdominal pain? *

  1. Diarrhea: 38 people, 57.58%
  2. Nausea (feeling of having an urge to vomit): 31 people, 46.97%
  3. Fatigue (feeling of tiredness): 24 people, 36.36%
  4. Hot Flush (sudden feelings of heat): 22 people, 33.33%
  5. Nausea And Vomiting: 19 people, 28.79%
  6. Weakness: 18 people, 27.27%
  7. Abdominal Discomfort: 16 people, 24.24%
  8. Weight Decreased: 14 people, 21.21%
  9. Muscle Aches (muscle pain): 14 people, 21.21%
  10. Sinusitis (inflammation of sinus): 13 people, 19.70%

What are the existing conditions these people have? *

  1. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 19 people, 28.79%
  2. Pulmonary Mass: 7 people, 10.61%
  3. Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 9.09%
  4. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 4.55%
  5. Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 3 people, 4.55%
  6. Asthma: 2 people, 3.03%
  7. Psoriasis (immune-mediated disease that affects the skin): 2 people, 3.03%
  8. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 3.03%
  9. High Blood Pressure: 2 people, 3.03%
  10. Hypopituitarism (diminished hormone secretion by the pituitary gland, causing dwarfism in children and premature aging in adults): 2 people, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Estrogel and have Abdominal pain?

- Check whether Abdominal pain is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrogel:

Abdominal pain treatments and more:

How severe was Abdominal pain and when was it recovered:

Expand to all the drugs that have ingredients of estradiol:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Estrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Abdominal pain:

Browse all the conditions that are associated with Abdominal pain:

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrogel) and Estrogel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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