Estrogel and Intervertebral disc degeneration - a phase IV clinical study of FDA data

Summary:

Intervertebral disc degeneration is reported as a side effect among people who take Estrogel (estradiol), especially for people who are female, 60+ old, also take Prometrium, and have Mouth ulcers.

The phase IV clinical study analyzes which people have Intervertebral disc degeneration when taking Estrogel. It is created by eHealthMe based on reports of 2,659 people who have side effects when taking Estrogel from the FDA, and is updated regularly.

What is Estrogel?

Estrogel has active ingredients of estradiol. It is often used in menopause. eHealthMe is studying from 2,921 Estrogel users. Check the latest studies of Estrogel.

What is Intervertebral disc degeneration?

Intervertebral disc degeneration (spinal disc degeneration) is found to be associated with 1,317 drugs and 1,493 conditions by eHealthMe. Check the latest studies of Intervertebral disc degeneration.

On Jul, 09, 2026

2,659 people reported to have side effects when taking Estrogel.
Among them, 14 people (0.53%) have Intervertebral disc degeneration.

Could Estrogel cause Intervertebral disc degeneration?

Among these 14 people:

What is the gender of people who have Intervertebral disc degeneration when taking Estrogel? *

female: 100 %
male: 0.0 %

What is the age of people who have Intervertebral disc degeneration when taking Estrogel? *

What are other drugs people take besides Estrogel? *

What are other side effects people have besides Intervertebral disc degeneration? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 10 people, 71.43%
Back Pain: 8 people, 57.14%
Malaise (a feeling of general discomfort or uneasiness): 8 people, 57.14%
Neck Pain: 8 people, 57.14%
Pain In Extremity: 6 people, 42.86%
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure): 3 people, 21.43%
Chickenpox (infection with varicella zoster virus): 3 people, 21.43%
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body): 3 people, 21.43%
Drug Ineffective: 3 people, 21.43%
Fever: 3 people, 21.43%

What are the existing conditions these people have? *

Nasal Ulcer (ulcer of nose): 3 people, 21.43%
Mouth Ulcers: 3 people, 21.43%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 14.29%
Depression: 2 people, 14.29%
Blood Cholesterol Decreased: 2 people, 14.29%
Neuralgia (pain in one or more nerves): 1 person, 7.14%
High Blood Pressure: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Estrogel and have Intervertebral disc degeneration?

- Check whether Intervertebral disc degeneration is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Estrogel:

Estrogel (2,921 reports)

Browse all side effects of Estrogel:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,317 drugs)

Browse all the conditions that are associated with Intervertebral disc degeneration:

Intervertebral disc degeneration (1,493 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol (the active ingredients of Estrogel) and Estrogel (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.