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Eszopiclone and Encephalopathy - a phase IV clinical study of FDA data

Summary:

Encephalopathy is reported as a side effect among people who take Eszopiclone (eszopiclone), especially for people who are female, 60+ old, also take Hydroxyzine, and have Depression.

The phase IV clinical study analyzes which people have Encephalopathy when taking Eszopiclone. It is created by eHealthMe based on reports of 4,164 people who have side effects when taking Eszopiclone from the FDA, and is updated regularly.

What is Eszopiclone?

Eszopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 4,258 Eszopiclone users. Check the latest studies of Eszopiclone.

What is Encephalopathy?

Encephalopathy (functioning of the brain is affected by some agent or condition) is found to be associated with 1,466 drugs and 1,602 conditions by eHealthMe. Check the latest studies of Encephalopathy.

On Jul, 10, 2026

4,164 people reported to have side effects when taking Eszopiclone.
Among them, 33 people (0.79%) have Encephalopathy.

Could Eszopiclone cause Encephalopathy?

Among these 33 people:

What is the gender of people who have Encephalopathy when taking Eszopiclone? *

  • female: 90.32 %
  • male: 9.68 %

What is the age of people who have Encephalopathy when taking Eszopiclone? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 48.39 %
  • 50-59: 3.23 %
  • 60+: 48.39 %

What are other drugs people take besides Eszopiclone? *

  1. Hydroxyzine: 12 people, 36.36%
  2. Mirtazapine: 11 people, 33.33%
  3. Donepezil: 8 people, 24.24%
  4. Lorazepam: 6 people, 18.18%
  5. Levetiracetam: 5 people, 15.15%
  6. Alprazolam: 4 people, 12.12%
  7. Donepezil Hydrochloride: 4 people, 12.12%
  8. Tizanidine Hydrochloride: 3 people, 9.09%
  9. Midazolam: 3 people, 9.09%
  10. Hydroxyzine Hydrochloride: 3 people, 9.09%

What are other side effects people have besides Encephalopathy? *

  1. Hypotension (abnormally low blood pressure): 16 people, 48.48%
  2. Overdose: 15 people, 45.45%
  3. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 12 people, 36.36%
  4. Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 12 people, 36.36%
  5. Unresponsive To Stimuli: 11 people, 33.33%
  6. Areflexia (absence of a reflex): 10 people, 30.30%
  7. Confusional State: 8 people, 24.24%
  8. Acute Psychosis (period of mentally unstable behaviour): 8 people, 24.24%
  9. Brain Death: 8 people, 24.24%
  10. Delusion (a false belief or opinion): 7 people, 21.21%

What are the existing conditions these people have? *

  1. Depression: 10 people, 30.30%
  2. Stress And Anxiety: 5 people, 15.15%
  3. Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 12.12%
  4. Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 2 people, 6.06%
  5. Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 2 people, 6.06%
  6. Sedation: 2 people, 6.06%
  7. Nausea (feeling of having an urge to vomit): 1 person, 3.03%
  8. Nosebleed (bleeding from nose): 1 person, 3.03%
  9. Lung Cancer - Non-Small Cell (lung cancer): 1 person, 3.03%
  10. Hypotension (abnormally low blood pressure): 1 person, 3.03%

* Approximation only. Some reports may have incomplete information.

Do you take Eszopiclone and have Encephalopathy?

- Check whether Encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eszopiclone:

Encephalopathy treatments and more:

How severe was Encephalopathy and when was it recovered:

Expand to all the drugs that have ingredients of eszopiclone:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Eszopiclone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Encephalopathy:

Browse all the conditions that are associated with Encephalopathy:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on eszopiclone (the active ingredients of Eszopiclone) and Eszopiclone (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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