Everolimus and Acute hepatic failure - a phase IV clinical study of FDA data

Summary:

Acute hepatic failure is reported as a side effect among people who take Everolimus (everolimus), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Prednisolone, and have Thrombotic microangiopathy.

The phase IV clinical study analyzes which people have Acute hepatic failure when taking Everolimus. It is created by eHealthMe based on reports of 16,218 people who have side effects when taking Everolimus from the FDA, and is updated regularly.

What is Everolimus?

Everolimus has active ingredients of everolimus. eHealthMe is studying from 16,228 Everolimus users. Check the latest studies of Everolimus.

What is Acute hepatic failure?

Acute hepatic failure is found to be associated with 710 drugs and 1,185 conditions by eHealthMe. Check the latest studies of Acute hepatic failure.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

16,218 people reported to have side effects when taking Everolimus.
Among them, 27 people (0.17%) have Acute hepatic failure.

Could Everolimus cause Acute hepatic failure?

Among these 27 people:

How long have people been on Everolimus when they have Acute hepatic failure? *

What is the gender of people who have Acute hepatic failure when taking Everolimus? *

female: 33.33 %
male: 66.67 %

What is the age of people who have Acute hepatic failure when taking Everolimus? *

What are other drugs people take besides Everolimus? *

Tacrolimus: 13 people, 48.15%
Prednisolone: 13 people, 48.15%
Mycophenolate Mofetil: 12 people, 44.44%
Budesonide: 11 people, 40.74%
Cyclosporine: 11 people, 40.74%
Methotrexate: 11 people, 40.74%
Cidofovir: 7 people, 25.93%
Zometa: 2 people, 7.41%
Exemestane: 2 people, 7.41%
Methimazole: 2 people, 7.41%

What are other side effects people have besides Acute hepatic failure? *

Cardiopulmonary Failure (cessation of normal circulation of the blood due to failure of the heart to contract): 11 people, 40.74%
Drug Ineffective: 10 people, 37.04%
Adenovirus Infection: 9 people, 33.33%
Hepatitis (inflammation of the liver): 7 people, 25.93%
Hepatitis B: 7 people, 25.93%
Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 6 people, 22.22%
Lactic Acidosis (low ph in body tissues): 6 people, 22.22%
Adenoviral Hepatitis (viral hepatitis): 6 people, 22.22%
Pneumonia: 6 people, 22.22%
Pneumonia Adenoviral (viral pneumonia caused by an adenovirus): 5 people, 18.52%

What are the existing conditions these people have? *

Thrombotic Microangiopathy (a pathology that results in thrombosis in capillaries and arterioles, due to an endothelial injury): 11 people, 40.74%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 8 people, 29.63%
Breast Cancer Metastatic: 5 people, 18.52%
Graft Versus Host Disease In Skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin): 4 people, 14.81%
Immunodeficiency Disorders: 4 people, 14.81%
Type 2 Diabetes: 3 people, 11.11%
Pancreatic Neuroendocrine Tumor: 3 people, 11.11%
Gastric Ulcer (stomach ulcer): 3 people, 11.11%
Breast Cancer: 2 people, 7.41%
Graft Versus Host Disease In Liver (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the liver): 2 people, 7.41%

* Approximation only. Some reports may have incomplete information.

Do you take Everolimus and have Acute hepatic failure?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Everolimus:

Everolimus (16,228 reports)

Browse all side effects of Everolimus:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute hepatic failure:

Acute hepatic failure (710 drugs)

Browse all the conditions that are associated with Acute hepatic failure:

Acute hepatic failure (1,185 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on everolimus (the active ingredients of Everolimus) and Everolimus (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.