Evoxac and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Evoxac (cevimeline hydrochloride), especially for people who are female, 50-59 old, also take Ambien, and have Breast cancer.

The phase IV clinical study analyzes which people have Major depression when taking Evoxac. It is created by eHealthMe based on reports of 1,960 people who have side effects when taking Evoxac from the FDA, and is updated regularly.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 800 drugs and 1,477 conditions by eHealthMe. Check the latest studies of Major depression.

On Aug, 05, 2026

1,960 people reported to have side effects when taking Evoxac.
Among them, 23 people (1.17%) have Major depression.

Among these 23 people:

What is the gender of people who have Major depression when taking Evoxac? *

female: 100 %
male: 0.0 %

What is the age of people who have Major depression when taking Evoxac? *

What are other drugs people take besides Evoxac? *

What are other side effects people have besides Major depression? *

Pain In Extremity: 22 people, 95.65%
Fall: 22 people, 95.65%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 22 people, 95.65%
Femur Fracture: 22 people, 95.65%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 19 people, 82.61%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 19 people, 82.61%
Urinary Tract Infection: 18 people, 78.26%
Groin Pain: 17 people, 73.91%
Flatulence (flatus expelled through the anus): 17 people, 73.91%
Foot Deformity (functional disability of foot): 17 people, 73.91%

What are the existing conditions these people have? *

Breast Cancer: 8 people, 34.78%
Osteopenia (a condition where bone mineral density is lower than normal): 5 people, 21.74%
Osteoporosis (bones weak and more likely to break): 4 people, 17.39%
Multiple Myeloma (cancer of the plasma cells): 4 people, 17.39%
Metastases To Bone (cancer spreads to bone): 4 people, 17.39%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 17.39%
Sleep Disorder: 1 person, 4.35%
Nervousness: 1 person, 4.35%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 4.35%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Evoxac and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Evoxac:

Evoxac (2,028 reports)

Major depression treatments and more:

Major depression (44,981 reports)

Browse all side effects of Evoxac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (800 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,477 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cevimeline hydrochloride (the active ingredients of Evoxac) and Evoxac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.