Evoxac and Sciatica - a phase IV clinical study of FDA data

Summary:

Sciatica is reported as a side effect among people who take Evoxac (cevimeline hydrochloride), especially for people who are female, 60+ old, also take Lyrica, and have Fibromyalgia.

The phase IV clinical study analyzes which people have Sciatica when taking Evoxac. It is created by eHealthMe based on reports of 1,960 people who have side effects when taking Evoxac from the FDA, and is updated regularly.

What is Evoxac?

Evoxac has active ingredients of cevimeline hydrochloride. It is often used in sjogren syndrome. eHealthMe is studying from 2,028 Evoxac users. Check the latest studies of Evoxac.

What is Sciatica?

Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve) is found to be associated with 1,144 drugs and 1,423 conditions by eHealthMe. Check the latest studies of Sciatica.

On Jan, 17, 2026

1,960 people reported to have side effects when taking Evoxac.
Among them, 13 people (0.66%) have Sciatica.

Among these 13 people:

What is the gender of people who have Sciatica when taking Evoxac? *

female: 84.62 %
male: 15.38 %

What is the age of people who have Sciatica when taking Evoxac? *

What are other drugs people take besides Evoxac? *

What are other side effects people have besides Sciatica? *

Nausea (feeling of having an urge to vomit): 5 people, 38.46%
Pain: 5 people, 38.46%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 30.77%
Fall: 4 people, 30.77%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 30.77%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 23.08%
Balance Disorder: 3 people, 23.08%
Joint Pain: 3 people, 23.08%
Speech Impairment (Adult) (inability to speak (adult)): 3 people, 23.08%
Fear Of Falling: 3 people, 23.08%

What are the existing conditions these people have? *

Fibromyalgia (a long-term condition which causes pain all over the body): 6 people, 46.15%
Pain: 5 people, 38.46%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 30.77%
Skin Irritation: 3 people, 23.08%
Nausea (feeling of having an urge to vomit): 3 people, 23.08%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 23.08%
Hypersensitivity: 3 people, 23.08%
Neuropathy Peripheral (surface nerve damage): 3 people, 23.08%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 15.38%
Glaucoma (increased fluid pressure in the eye with vision loss): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

Do you take Evoxac and have Sciatica?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Evoxac:

Evoxac (2,028 reports)

Sciatica treatments and more:

Sciatica (28,508 reports)

Browse all side effects of Evoxac:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sciatica:

Sciatica (1,144 drugs)

Browse all the conditions that are associated with Sciatica:

Sciatica (1,423 conditions)

Drugs similar to Evoxac and Sciatica :

Plaquenil side effect: Sciatica

How the study uses the data?

The study uses data from the FDA. It is based on cevimeline hydrochloride (the active ingredients of Evoxac) and Evoxac (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.