Excedrin and Ankylosing spondylitis - a phase IV clinical study of FDA data

Summary:

Ankylosing spondylitis is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Synthroid, and have Bipolar disorder.

The phase IV clinical study analyzes which people have Ankylosing spondylitis when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Ankylosing spondylitis?

Ankylosing spondylitis (type of arthritis affecting the spine) is found to be associated with 746 drugs and 1,048 conditions by eHealthMe. Check the latest studies of Ankylosing spondylitis.

On Jul, 19, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 17 people (0.08%) have Ankylosing spondylitis.

Could Excedrin cause Ankylosing spondylitis?

Among these 17 people:

How long have people been on Excedrin when they have Ankylosing spondylitis? *

What is the gender of people who have Ankylosing spondylitis when taking Excedrin? *

female: 88.24 %
male: 11.76 %

What is the age of people who have Ankylosing spondylitis when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Ankylosing spondylitis? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 29.41%
Claustrophobia (fear of having no escape and being closed in small spaces): 5 people, 29.41%
Joint Swelling: 5 people, 29.41%
Itching: 4 people, 23.53%
Back Pain: 4 people, 23.53%
Muscle Spasms (muscle contraction): 4 people, 23.53%
Spinal Osteoarthritis (joint cartilage loss in spine): 4 people, 23.53%
Diarrhea: 4 people, 23.53%
Loss Of Consciousness: 4 people, 23.53%
Insomnia (sleeplessness): 3 people, 17.65%

What are the existing conditions these people have? *

Bipolar Disorder (mood disorder): 3 people, 17.65%
Breast Cancer: 2 people, 11.76%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 11.76%
Tension Headache: 1 person, 5.88%
Inflammation: 1 person, 5.88%
Blood Pressure Abnormal: 1 person, 5.88%
Gait Disturbance: 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%
Hair Loss: 1 person, 5.88%
Indigestion: 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Ankylosing spondylitis?

- Check whether Ankylosing spondylitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Ankylosing spondylitis treatments and more:

Ankylosing spondylitis (130,235 reports)

How severe was Ankylosing spondylitis and when was it recovered:

Ankylosing spondylitis in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Ankylosing spondylitis and drugs with ingredients of acetaminophen; aspirin; caffeine

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.