Excedrin and Dependence - a phase IV clinical study of FDA data

Summary:

Dependence is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 40-49 old, have been taking the drug for 10+ years also take Prilosec, and have Thyroid diseases.

The phase IV clinical study analyzes which people have Dependence when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Dependence?

Dependence is found to be associated with 416 drugs and 452 conditions by eHealthMe. Check the latest studies of Dependence.

On May, 14, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 36 people (0.17%) have Dependence.

Among these 36 people:

How long have people been on Excedrin when they have Dependence? *

What is the gender of people who have Dependence when taking Excedrin? *

female: 73.08 %
male: 26.92 %

What is the age of people who have Dependence when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Dependence? *

Drug Ineffective: 11 people, 30.56%
Oedema Peripheral (superficial swelling): 8 people, 22.22%
Dyspnea (difficult or laboured breathing): 8 people, 22.22%
Depression: 8 people, 22.22%
Insomnia (sleeplessness): 8 people, 22.22%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 7 people, 19.44%
Fatigue (feeling of tiredness): 7 people, 19.44%
Duodenal Ulcer Perforation (untreated ulcer can burn through the wall of the stomach): 7 people, 19.44%
Hip Fracture: 7 people, 19.44%
Cuts And Puncture Wounds: 7 people, 19.44%

What are the existing conditions these people have? *

Thyroid Diseases: 7 people, 19.44%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 11.11%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 11.11%
Osteoporosis (bones weak and more likely to break): 3 people, 8.33%
Tension Headache: 2 people, 5.56%
Spinal Osteoarthritis (joint cartilage loss in spine): 1 person, 2.78%
Indigestion: 1 person, 2.78%
High Blood Cholesterol: 1 person, 2.78%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Dependence?

- Check whether Dependence is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Dependence treatments and more:

Dependence (56,849 reports)

How severe was Dependence and when was it recovered:

Dependence in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Dependence and drugs with ingredients of acetaminophen; aspirin; caffeine

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Dependence:

Dependence (416 drugs)

Browse all the conditions that are associated with Dependence:

Dependence (452 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.