Excedrin and Gallbladder attack - a phase IV clinical study of FDA data

Summary:

Gallbladder attack is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 20-29 old, also take Yaz, and have Procedural pain.

The phase IV clinical study analyzes which people have Gallbladder attack when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Gallbladder attack?

Gallbladder attack (gallstones, gallbladder disease and gallbladder pain) is found to be associated with 576 drugs and 995 conditions by eHealthMe. Check the latest studies of Gallbladder attack.

On Apr, 13, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 21 people (0.1%) have Gallbladder attack.

Could Excedrin cause Gallbladder attack?

Among these 21 people:

What is the gender of people who have Gallbladder attack when taking Excedrin? *

female: 100 %
male: 0.0 %

What is the age of people who have Gallbladder attack when taking Excedrin? *

What are other drugs people take besides Excedrin? *

Yaz: 14 people, 66.67%
Yasmin: 11 people, 52.38%
Ibuprofen: 8 people, 38.10%
Vicodin: 6 people, 28.57%
Azithromycin: 6 people, 28.57%
Sertraline Hydrochloride: 4 people, 19.05%
Zetia: 3 people, 14.29%
Fenofibrate: 3 people, 14.29%
Maxzide: 3 people, 14.29%
Lortab: 3 people, 14.29%

What are other side effects people have besides Gallbladder attack? *

Cholecystitis Chronic (long lasting infection of gallbladder): 13 people, 61.90%
Gallstones (stone formation by bile component): 12 people, 57.14%
Emotional Distress: 8 people, 38.10%
Injury: 8 people, 38.10%
Nausea (feeling of having an urge to vomit): 8 people, 38.10%
Abdominal Pain Upper: 6 people, 28.57%
Stress And Anxiety: 5 people, 23.81%
Gallbladder Disorder: 5 people, 23.81%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 4 people, 19.05%
Diarrhea: 4 people, 19.05%

What are the existing conditions these people have? *

Premenstrual Syndrome: 5 people, 23.81%
Procedural Pain: 5 people, 23.81%
Hyperlipidaemia (presence of excess lipids in the blood): 3 people, 14.29%
Hypertriglyceridaemia (excess of triglycerides in the blood): 3 people, 14.29%
Anaemia (lack of blood): 3 people, 14.29%
High Blood Pressure: 3 people, 14.29%
Joint Pain: 3 people, 14.29%
Birth Control: 2 people, 9.52%
Blood Glucose Abnormal: 2 people, 9.52%
Dysmenorrhea (painful menstruation): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Gallbladder attack?

- Check whether Gallbladder attack is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Gallbladder attack treatments and more:

Gallbladder attack (4,101 reports)

How severe was Gallbladder attack and when was it recovered:

Gallbladder attack in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Gallbladder attack and drugs with ingredients of acetaminophen; aspirin; caffeine (21 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder attack:

Gallbladder attack (576 drugs)

Browse all the conditions that are associated with Gallbladder attack:

Gallbladder attack (995 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.