Excedrin and Heart disease - a phase IV clinical study of FDA data

Summary:

Heart disease is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 60+ old, also take Fosamax, and have High blood cholesterol.

The phase IV clinical study analyzes which people have Heart disease when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Heart disease?

Heart disease is found to be associated with 1,054 drugs and 1,443 conditions by eHealthMe. Check the latest studies of Heart disease.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 11 people (0.05%) have Heart disease.

Among these 11 people:

What is the gender of people who have Heart disease when taking Excedrin? *

female: 80 %
male: 20 %

What is the age of people who have Heart disease when taking Excedrin? *

What are other drugs people take besides Excedrin? *

Lipitor: 4 people, 36.36%
Ambien: 4 people, 36.36%
Trazodone Hydrochloride: 4 people, 36.36%
Boniva: 4 people, 36.36%
Fosamax: 4 people, 36.36%
Vioxx: 2 people, 18.18%
Nuvaring: 2 people, 18.18%
Pepcid: 2 people, 18.18%
Zantac: 1 person, 9.09%
Folic Acid: 1 person, 9.09%

What are other side effects people have besides Heart disease? *

Weakness: 5 people, 45.45%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 5 people, 45.45%
Herpes Zoster: 5 people, 45.45%
Stress And Anxiety: 5 people, 45.45%
Depression: 5 people, 45.45%
Fatigue (feeling of tiredness): 5 people, 45.45%
Muscle Aches (muscle pain): 5 people, 45.45%
Dyspnea (difficult or laboured breathing): 5 people, 45.45%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 5 people, 45.45%
Fall: 4 people, 36.36%

What are the existing conditions these people have? *

High Blood Cholesterol: 5 people, 45.45%
Osteoporosis (bones weak and more likely to break): 4 people, 36.36%
Insomnia (sleeplessness): 4 people, 36.36%
Birth Control: 3 people, 27.27%
Stress And Anxiety: 1 person, 9.09%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 9.09%
Nervous System Disorder (a general class of medical conditions affecting the nervous system): 1 person, 9.09%
Indigestion: 1 person, 9.09%
High Blood Pressure: 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Heart disease?

- Check whether Heart disease is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Heart disease treatments and more:

Heart disease (42,698 reports)

How severe was Heart disease and when was it recovered:

Heart disease in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Heart disease and drugs with ingredients of acetaminophen; aspirin; caffeine (13 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Heart disease:

Heart disease (1,054 drugs)

Browse all the conditions that are associated with Heart disease:

Heart disease (1,443 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.