Excedrin and Hyperthyroidism - a phase IV clinical study of FDA data

Summary:

Hyperthyroidism is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 30-39 old, also take Naproxen, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Hyperthyroidism when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Hyperthyroidism?

Hyperthyroidism (over activity of the thyroid gland) is found to be associated with 996 drugs and 1,435 conditions by eHealthMe. Check the latest studies of Hyperthyroidism.

On May, 12, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 11 people (0.05%) have Hyperthyroidism.

Among these 11 people:

What is the gender of people who have Hyperthyroidism when taking Excedrin? *

female: 90.91 %
male: 9.09 %

What is the age of people who have Hyperthyroidism when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Hyperthyroidism? *

Nausea (feeling of having an urge to vomit): 5 people, 45.45%
Hyperhidrosis (abnormally increased sweating): 4 people, 36.36%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 36.36%
Dizziness: 4 people, 36.36%
Paleness (unusual lightness of skin colour): 4 people, 36.36%
Electrocardiogram T Wave Abnormal: 4 people, 36.36%
Retching (strong involuntary effort to vomit): 4 people, 36.36%
Sinus Tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node): 4 people, 36.36%
Speech Disorder: 4 people, 36.36%
Autoimmune Disorder (a condition in which the immune system attacks the body's normal substances and tissue): 4 people, 36.36%

What are the existing conditions these people have? *

Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 36.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 18.18%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 2 people, 18.18%
Birth Control: 2 people, 18.18%
Sinus Disorder (disease of sinus): 1 person, 9.09%
Pain In Extremity: 1 person, 9.09%
Osteoporosis (bones weak and more likely to break): 1 person, 9.09%
Muscle Spasms (muscle contraction): 1 person, 9.09%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 9.09%
Mitral Valve Prolapse (heart's mitral valve doesn't work well): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Hyperthyroidism?

- Check whether Hyperthyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Hyperthyroidism treatments and more:

Hyperthyroidism (26,832 reports)

How severe was Hyperthyroidism and when was it recovered:

Hyperthyroidism in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Hyperthyroidism and drugs with ingredients of acetaminophen; aspirin; caffeine (10 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperthyroidism:

Hyperthyroidism (996 drugs)

Browse all the conditions that are associated with Hyperthyroidism:

Hyperthyroidism (1,435 conditions)

Related publications that referenced our studies

Dulani S, Dulani R, Lele S, Diagavane S, Anjankar S, Jaiswal N, Subramaniam PS, Juneja R, "Chronic Subdural Haematoma in a Case of Hyperthyroidism Presenting with Papilledema", Chinese Medicine, 2012 Dec .
Dulani S, Dulani R, Lele S, Diagavane S, Anjankar S, Jaiswal N, Subramaniam PS, Juneja R, "Chronic Subdural Haematoma in a Case of Hyperthyroidism Presenting with Papilledema", Chinese Medicine, 2012 Dec .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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