Excedrin and Irregular heartbeat - a phase IV clinical study of FDA data

Summary:

Irregular heartbeat is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Tylenol, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Irregular heartbeat when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Irregular heartbeat?

Irregular heartbeat is found to be associated with 3,913 drugs and 3,796 conditions by eHealthMe. Check the latest studies of Irregular heartbeat.

On Mar, 28, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 258 people (1.19%) have Irregular heartbeat.

Could Excedrin cause Irregular heartbeat?

Among these 258 people:

How long have people been on Excedrin when they have Irregular heartbeat? *

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What is the gender of people who have Irregular heartbeat when taking Excedrin? *

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* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Irregular heartbeat?

- Check whether Irregular heartbeat is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Irregular heartbeat treatments and more:

Irregular heartbeat (147,649 reports)

How severe was Irregular heartbeat and when was it recovered:

Irregular heartbeat in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Irregular heartbeat and drugs with ingredients of acetaminophen; aspirin; caffeine (293 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irregular heartbeat:

Irregular heartbeat (3,913 drugs)

Browse all the conditions that are associated with Irregular heartbeat:

Irregular heartbeat (3,796 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.