Excedrin and Local swelling - a phase IV clinical study of FDA data

Summary:

Local swelling is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Prednisone, and have Eczema.

The phase IV clinical study analyzes which people have Local swelling when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Local swelling?

Local swelling (swelling at the site of some application of substance or injury) is found to be associated with 1,010 drugs and 1,404 conditions by eHealthMe. Check the latest studies of Local swelling.

On Jul, 19, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 28 people (0.13%) have Local swelling.

Among these 28 people:

How long have people been on Excedrin when they have Local swelling? *

What is the gender of people who have Local swelling when taking Excedrin? *

female: 74.07 %
male: 25.93 %

What is the age of people who have Local swelling when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Local swelling? *

Rashes (redness): 7 people, 25.00%
Itching: 6 people, 21.43%
Urticaria (rash of round, red welts on the skin that itch intensely): 5 people, 17.86%
Wound Infection Staphylococcal: 4 people, 14.29%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 4 people, 14.29%
Respiratory Tract Congestion (blockage on respiratory system): 4 people, 14.29%
Seborrhoeic Keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest): 4 people, 14.29%
Sinusitis (inflammation of sinus): 4 people, 14.29%
Hepatomegaly (abnormal enlargement of the liver): 4 people, 14.29%
Skin Blushing/flushing (a sudden reddening of the face, neck): 4 people, 14.29%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 14.29%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 14.29%
High Blood Pressure: 3 people, 10.71%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 7.14%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.14%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 7.14%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 3.57%
Fracture Pain: 1 person, 3.57%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 3.57%
Drowsiness: 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Local swelling?

- Check whether Local swelling is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Local swelling treatments and more:

Local swelling (21,122 reports)

How severe was Local swelling and when was it recovered:

Local swelling in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Local swelling and drugs with ingredients of acetaminophen; aspirin; caffeine (28 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Local swelling:

Local swelling (1,010 drugs)

Browse all the conditions that are associated with Local swelling:

Local swelling (1,404 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.