Excedrin and Melaena - a phase IV clinical study of FDA data

Summary:

Melaena is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are male, 60+ old, also take Aspirin, and have Bone loss.

The phase IV clinical study analyzes which people have Melaena when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Melaena?

Melaena (the passage of black, tarry stools) is found to be associated with 1,321 drugs and 1,475 conditions by eHealthMe. Check the latest studies of Melaena.

On Jul, 16, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 37 people (0.17%) have Melaena.

Among these 37 people:

What is the gender of people who have Melaena when taking Excedrin? *

female: 43.24 %
male: 56.76 %

What is the age of people who have Melaena when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Melaena? *

Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 20 people, 54.05%
Gastritis (inflammation of stomach): 16 people, 43.24%
Dyspnea (difficult or laboured breathing): 15 people, 40.54%
Abdominal Pain Upper: 14 people, 37.84%
Tremor (trembling or shaking movements in one or more parts of your body): 14 people, 37.84%
High Blood Pressure: 14 people, 37.84%
Iron Deficiency Anaemia: 14 people, 37.84%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 14 people, 37.84%
Sinusitis (inflammation of sinus): 13 people, 35.14%
Fainting (loss of consciousness and postural tone): 13 people, 35.14%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 12 people, 32.43%
Bone Loss: 12 people, 32.43%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 8 people, 21.62%
Osteoporosis (bones weak and more likely to break): 6 people, 16.22%
Broken Bone: 5 people, 13.51%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 8.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.41%
Birth Control: 2 people, 5.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 2.70%
Neuralgia (pain in one or more nerves): 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Melaena?

- Check whether Melaena is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Melaena treatments and more:

Melaena (29,850 reports)

How severe was Melaena and when was it recovered:

Melaena in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Melaena and drugs with ingredients of acetaminophen; aspirin; caffeine

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Melaena:

Melaena (1,321 drugs)

Browse all the conditions that are associated with Melaena:

Melaena (1,475 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.