Excedrin and Sinus tachycardia - a phase IV clinical study of FDA data

Summary:

Sinus tachycardia is reported as a side effect among people who take Excedrin (acetaminophen; aspirin; caffeine), especially for people who are female, 60+ old, also take Tylenol, and have Relapsing-remitting multiple sclerosis.

The phase IV clinical study analyzes which people have Sinus tachycardia when taking Excedrin. It is created by eHealthMe based on reports of 21,620 people who have side effects when taking Excedrin from the FDA, and is updated regularly.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

What is Sinus tachycardia?

Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node) is found to be associated with 1,265 drugs and 1,412 conditions by eHealthMe. Check the latest studies of Sinus tachycardia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

21,620 people reported to have side effects when taking Excedrin.
Among them, 24 people (0.11%) have Sinus tachycardia.

Among these 24 people:

What is the gender of people who have Sinus tachycardia when taking Excedrin? *

female: 70.83 %
male: 29.17 %

What is the age of people who have Sinus tachycardia when taking Excedrin? *

What are other drugs people take besides Excedrin? *

What are other side effects people have besides Sinus tachycardia? *

Nausea (feeling of having an urge to vomit): 12 people, 50.00%
Chest Pain: 9 people, 37.50%
Dizziness: 9 people, 37.50%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 9 people, 37.50%
Dyspnea (difficult or laboured breathing): 8 people, 33.33%
Paleness (unusual lightness of skin colour): 7 people, 29.17%
Fatigue (feeling of tiredness): 7 people, 29.17%
White Blood Cell Count Increased: 6 people, 25.00%
Back Pain: 6 people, 25.00%
Weight Increased: 5 people, 20.83%

What are the existing conditions these people have? *

Birth Control: 3 people, 12.50%
High Blood Pressure: 3 people, 12.50%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 12.50%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 8.33%
Primary Myelofibrosis (primary disorder of the bone marrow): 2 people, 8.33%
Oesophageal Ulcer (ulcer of oesophagus): 2 people, 8.33%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 8.33%
High Blood Cholesterol: 2 people, 8.33%
Muscle Spasms (muscle contraction): 2 people, 8.33%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Excedrin and have Sinus tachycardia?

- Check whether Sinus tachycardia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Excedrin:

Excedrin (22,740 reports)

Sinus tachycardia treatments and more:

Sinus tachycardia (20,949 reports)

How severe was Sinus tachycardia and when was it recovered:

Sinus tachycardia in Excedrin

Expand to all the drugs that have ingredients of acetaminophen; aspirin; caffeine:

Sinus tachycardia and drugs with ingredients of acetaminophen; aspirin; caffeine (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Excedrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus tachycardia:

Sinus tachycardia (1,265 drugs)

Browse all the conditions that are associated with Sinus tachycardia:

Sinus tachycardia (1,412 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; aspirin; caffeine (the active ingredients of Excedrin) and Excedrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.