Eylea and Cognitive disorder - a phase IV clinical study of FDA data

Summary:

Cognitive disorder is reported as a side effect among people who take Eylea (aflibercept), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Clexane, and have High blood pressure.

The phase IV clinical study analyzes which people have Cognitive disorder when taking Eylea. It is created by eHealthMe based on reports of 27,819 people who have side effects when taking Eylea from the FDA, and is updated regularly.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

What is Cognitive disorder?

Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving) is found to be associated with 1,646 drugs and 1,730 conditions by eHealthMe. Check the latest studies of Cognitive disorder.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

27,819 people reported to have side effects when taking Eylea.
Among them, 22 people (0.08%) have Cognitive disorder.

Among these 22 people:

How long have people been on Eylea when they have Cognitive disorder? *

What is the gender of people who have Cognitive disorder when taking Eylea? *

female: 86.67 %
male: 13.33 %

What is the age of people who have Cognitive disorder when taking Eylea? *

What are other drugs people take besides Eylea? *

What are other side effects people have besides Cognitive disorder? *

Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 10 people, 45.45%
Metastases To Central Nervous System (cancer spreads to central nervous system): 10 people, 45.45%
Personality Change: 10 people, 45.45%
Functional Gastrointestinal Disorder (functional problem in separate organs of gastrointestinal system): 10 people, 45.45%
Chronic Kidney Disease: 10 people, 45.45%
Nausea And Vomiting: 10 people, 45.45%
Metastases To Lung (cancer spreads to lung): 10 people, 45.45%
Brain Neoplasm (tumour of brain): 10 people, 45.45%
Urinary Retention (the inability to completely or partially empty the bladder): 10 people, 45.45%
Drug Intolerance (drug sensitivity): 10 people, 45.45%

What are the existing conditions these people have? *

High Blood Pressure: 10 people, 45.45%
Age-Related Macular Degeneration: 3 people, 13.64%
Transient Ischaemic Attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)): 2 people, 9.09%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 2 people, 9.09%
Rashes (redness): 2 people, 9.09%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 1 person, 4.55%
Eye Inflammation: 1 person, 4.55%
Dry Eyes (lack of adequate tears): 1 person, 4.55%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 1 person, 4.55%
Conjunctivitis Allergic (inflammation of the conjunctiva due to allergy): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Eylea and have Cognitive disorder?

- Check whether Cognitive disorder is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eylea:

Eylea (27,868 reports)

Browse all side effects of Eylea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cognitive disorder:

Cognitive disorder (1,646 drugs)

Browse all the conditions that are associated with Cognitive disorder:

Cognitive disorder (1,730 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aflibercept (the active ingredients of Eylea) and Eylea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.