Eylea and Hypertensive crisis - a phase IV clinical study of FDA data

Summary:

Hypertensive crisis is reported as a side effect among people who take Eylea (aflibercept), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Avastin, and have High blood pressure.

The phase IV clinical study analyzes which people have Hypertensive crisis when taking Eylea. It is created by eHealthMe based on reports of 27,819 people who have side effects when taking Eylea from the FDA, and is updated regularly.

What is Eylea?

Eylea has active ingredients of aflibercept. It is often used in macular degeneration. eHealthMe is studying from 27,868 Eylea users. Check the latest studies of Eylea.

What is Hypertensive crisis?

Hypertensive crisis is found to be associated with 786 drugs and 932 conditions by eHealthMe. Check the latest studies of Hypertensive crisis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

27,819 people reported to have side effects when taking Eylea.
Among them, 22 people (0.08%) have Hypertensive crisis.

Among these 22 people:

How long have people been on Eylea when they have Hypertensive crisis? *

What is the gender of people who have Hypertensive crisis when taking Eylea? *

female: 85.71 %
male: 14.29 %

What is the age of people who have Hypertensive crisis when taking Eylea? *

What are other drugs people take besides Eylea? *

What are other side effects people have besides Hypertensive crisis? *

Osteoarthritis (a joint disease caused by cartilage loss in a joint): 3 people, 13.64%
Vision Blurred: 2 people, 9.09%
Headache (pain in head): 2 people, 9.09%
Heart Attack: 2 people, 9.09%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 9.09%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 2 people, 9.09%
Lung Disorder (lung disease): 2 people, 9.09%
Eye Pain: 2 people, 9.09%
Back Pain: 2 people, 9.09%
Atherosclerosis (disorder of the arteries): 2 people, 9.09%

What are the existing conditions these people have? *

High Blood Pressure: 7 people, 31.82%
Age-Related Macular Degeneration: 6 people, 27.27%
Diabetic Retinal Oedema (excessive build-up of fluid in the retina due to diabetes): 4 people, 18.18%
Retinal Vessel Occlusion (a blockage in one of the small arteries): 3 people, 13.64%
Diabetes: 2 people, 9.09%
Retinopathy Of Prematurity (retina damage in premature): 1 person, 4.55%
Retinopathy Hypertensive (acute damage to the retina of the eye due to high blood pressure): 1 person, 4.55%
Maculopathy (a condition or disease of the macula, the small spot in the retina where vision is keenest): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Eylea and have Hypertensive crisis?

- Check whether Hypertensive crisis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Eylea:

Eylea (27,868 reports)

Browse all side effects of Eylea:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypertensive crisis:

Hypertensive crisis (786 drugs)

Browse all the conditions that are associated with Hypertensive crisis:

Hypertensive crisis (932 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aflibercept (the active ingredients of Eylea) and Eylea (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.