Femring and Vulvovaginal pain - a phase IV clinical study of FDA data

Summary:

Vulvovaginal pain is reported as a side effect among people who take Femring (estradiol acetate), especially for people who are 60+ old, have been taking the drug for < 1 month also take Humalog, and have Menopausal symptoms.

The phase IV clinical study analyzes which people have Vulvovaginal pain when taking Femring. It is created by eHealthMe based on reports of 696 people who have side effects when taking Femring from the FDA, and is updated regularly.

What is Femring?

Femring has active ingredients of estradiol acetate. It is often used in menopause. eHealthMe is studying from 721 Femring users. Check the latest studies of Femring.

What is Vulvovaginal pain?

Vulvovaginal pain is found to be associated with 295 drugs and 443 conditions by eHealthMe. Check the latest studies of Vulvovaginal pain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

696 people reported to have side effects when taking Femring.
Among them, 11 people (1.58%) have Vulvovaginal pain.

Among these 11 people:

How long have people been on Femring when they have Vulvovaginal pain? *

What is the age of people who have Vulvovaginal pain when taking Femring? *

What are other drugs people take besides Femring? *

What are other side effects people have besides Vulvovaginal pain? *

Vulvovaginal Burning Sensation: 4 people, 36.36%
Vulvovaginal Dryness: 3 people, 27.27%
Abdominal Discomfort: 2 people, 18.18%
Vulvovaginal Mycotic Infection (vulvovaginal fungal infection): 2 people, 18.18%
Abdominal Pain: 2 people, 18.18%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 1 person, 9.09%
Abdominal Distension: 1 person, 9.09%
Abdominal Pain Lower: 1 person, 9.09%
Atrophic Vulvovaginitis (inflammation of the vulva): 1 person, 9.09%
Discomfort: 1 person, 9.09%

What are the existing conditions these people have? *

Menopausal Symptoms: 3 people, 27.27%
Vulvovaginal Dryness: 2 people, 18.18%
High Blood Pressure: 2 people, 18.18%
Stress And Anxiety: 1 person, 9.09%
Sexual Intercourse - Painful: 1 person, 9.09%
Seasonal Allergy (allergic condition due to certain season): 1 person, 9.09%
Irritable Bowel Syndrome: 1 person, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
Hot Flush (sudden feelings of heat): 1 person, 9.09%
Dry Eyes (lack of adequate tears): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Femring and have Vulvovaginal pain?

- Check whether Vulvovaginal pain is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Femring:

Femring (721 reports)

Browse all side effects of Femring:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Vulvovaginal pain:

Vulvovaginal pain (295 drugs)

Browse all the conditions that are associated with Vulvovaginal pain:

Vulvovaginal pain (443 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on estradiol acetate (the active ingredients of Femring) and Femring (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.