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Fentanyl transdermal system and Application site scar - a phase IV clinical study of FDA data

Summary:

Application site scar is reported as a side effect among people who take Fentanyl transdermal system (fentanyl), especially for people who are female, 50-59 old, have been taking the drug for 6 - 12 months also take Duragesic-100, and have Breakthrough pain.

The phase IV clinical study analyzes which people have Application site scar when taking Fentanyl transdermal system. It is created by eHealthMe based on reports of 5,639 people who have side effects when taking Fentanyl transdermal system from the FDA, and is updated regularly.

What is Fentanyl transdermal system?

Fentanyl transdermal system has active ingredients of fentanyl. It is often used in pain. eHealthMe is studying from 5,728 Fentanyl transdermal system users. Check the latest studies of Fentanyl transdermal system.

What is Application site scar?

Application site scar is found to be associated with 82 drugs and 251 conditions by eHealthMe. Check the latest studies of Application site scar.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

5,639 people reported to have side effects when taking Fentanyl transdermal system.
Among them, 12 people (0.21%) have Application site scar.

Could Fentanyl transdermal system cause Application site scar?

Among these 12 people:

How long have people been on Fentanyl transdermal system when they have Application site scar? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 100 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Application site scar when taking Fentanyl transdermal system? *

  • female: 58.33 %
  • male: 41.67 %

What is the age of people who have Application site scar when taking Fentanyl transdermal system? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 33.33 %
  • 50-59: 55.56 %
  • 60+: 11.11 %

What are other drugs people take besides Fentanyl transdermal system? *

  1. Duragesic-100: 4 people, 33.33%
  2. Lyrica: 3 people, 25.00%
  3. Klonopin: 3 people, 25.00%
  4. Vicodin: 2 people, 16.67%
  5. Cymbalta: 2 people, 16.67%
  6. Lortab: 1 person, 8.33%
  7. Avapro: 1 person, 8.33%
  8. Coreg: 1 person, 8.33%
  9. Desyrel: 1 person, 8.33%
  10. Fentanyl Citrate: 1 person, 8.33%

What are other side effects people have besides Application site scar? *

  1. Application Site Erythema (redness of the skin at application site): 7 people, 58.33%
  2. Dermatitis Contact (skin reaction (dermatitis) resulting from exposure to allergens): 4 people, 33.33%
  3. Application Site Discoloration: 2 people, 16.67%
  4. Pain In Extremity: 2 people, 16.67%
  5. Overdose: 2 people, 16.67%
  6. Application Site Erosion: 2 people, 16.67%
  7. Application Site Irritation: 2 people, 16.67%
  8. Withdrawal Syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance): 1 person, 8.33%
  9. Application Site Scab (hard coating on the skin formed at application site): 1 person, 8.33%
  10. Application Site Burn: 1 person, 8.33%

What are the existing conditions these people have? *

  1. Breakthrough Pain: 4 people, 33.33%
  2. Sleep Disorder: 2 people, 16.67%
  3. Joint Pain: 2 people, 16.67%
  4. Depression: 2 people, 16.67%
  5. Seasonal Allergy (allergic condition due to certain season): 1 person, 8.33%
  6. Procedural Pain: 1 person, 8.33%
  7. Neuropathy Peripheral (surface nerve damage): 1 person, 8.33%
  8. Muscle Spasms (muscle contraction): 1 person, 8.33%
  9. High Blood Pressure: 1 person, 8.33%
  10. Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Fentanyl transdermal system and have Application site scar?

- Check whether Application site scar is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fentanyl transdermal system:

Application site scar treatments and more:

How severe was Application site scar and when was it recovered:

Expand to all the drugs that have ingredients of fentanyl:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fentanyl transdermal system:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site scar:

Browse all the conditions that are associated with Application site scar:

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl (the active ingredients of Fentanyl transdermal system) and Fentanyl transdermal system (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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