Fentanyl and Major depression - a phase IV clinical study of FDA data

Summary:

Major depression is reported as a side effect among people who take Fentanyl (fentanyl citrate), especially for people who are female, 50-59 old, also take Ambien, and have Breast cancer.

The phase IV clinical study analyzes which people have Major depression when taking Fentanyl. It is created by eHealthMe based on reports of 72,646 people who have side effects when taking Fentanyl from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Major depression?

Major depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings) is found to be associated with 801 drugs and 1,476 conditions by eHealthMe. Check the latest studies of Major depression.

On Jul, 16, 2026

72,646 people reported to have side effects when taking Fentanyl.
Among them, 70 people (0.1%) have Major depression.

Among these 70 people:

What is the gender of people who have Major depression when taking Fentanyl? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Major depression when taking Fentanyl? *

What are other drugs people take besides Fentanyl? *

What are other side effects people have besides Major depression? *

Stress And Anxiety: 48 people, 68.57%
Joint Pain: 43 people, 61.43%
Pain In Extremity: 36 people, 51.43%
Injury: 34 people, 48.57%
Urinary Tract Infection: 34 people, 48.57%
Hypoaesthesia (reduced sense of touch or sensation): 34 people, 48.57%
Fall: 34 people, 48.57%
Osteonecrosis Of Jaw (death of bone of jaw): 32 people, 45.71%
Nausea (feeling of having an urge to vomit): 30 people, 42.86%
Fever: 29 people, 41.43%

What are the existing conditions these people have? *

Breast Cancer: 21 people, 30.00%
Depression: 12 people, 17.14%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 11 people, 15.71%
Breast Cancer Metastatic: 10 people, 14.29%
Insomnia (sleeplessness): 9 people, 12.86%
Ill-Defined Disorder: 8 people, 11.43%
Sleep Disorder: 7 people, 10.00%
Metastases To Bone (cancer spreads to bone): 7 people, 10.00%
Stress And Anxiety: 5 people, 7.14%
Multiple Myeloma (cancer of the plasma cells): 3 people, 4.29%

* Approximation only. Some reports may have incomplete information.

Do you take Fentanyl and have Major depression?

- Check whether Major depression is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fentanyl:

Fentanyl (73,301 reports)

Major depression treatments and more:

Major depression (44,979 reports)

Browse all side effects of Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Major depression:

Major depression (801 drugs)

Browse all the conditions that are associated with Major depression:

Major depression (1,476 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Fentanyl) and Fentanyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.