Fentanyl and Second primary malignancy - a phase IV clinical study of FDA data

Summary:

Second primary malignancy is reported as a side effect among people who take Fentanyl (fentanyl citrate), especially for people who are female, 60+ old, also take Zometa, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Second primary malignancy when taking Fentanyl. It is created by eHealthMe based on reports of 72,646 people who have side effects when taking Fentanyl from the FDA, and is updated regularly.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

What is Second primary malignancy?

Second primary malignancy (after getting cure a cancer, a new cancer development) is found to be associated with 579 drugs and 460 conditions by eHealthMe. Check the latest studies of Second primary malignancy.

On Jan, 15, 2026

72,646 people reported to have side effects when taking Fentanyl.
Among them, 25 people (0.03%) have Second primary malignancy.

Could Fentanyl cause Second primary malignancy?

Among these 25 people:

What is the gender of people who have Second primary malignancy when taking Fentanyl? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Second primary malignancy when taking Fentanyl? *

What are other drugs people take besides Fentanyl? *

What are other side effects people have besides Second primary malignancy? *

Osteonecrosis Of Jaw (death of bone of jaw): 17 people, 68.00%
Stress And Anxiety: 17 people, 68.00%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 15 people, 60.00%
Anaemia (lack of blood): 14 people, 56.00%
Dizziness: 14 people, 56.00%
Exposed Bone In Jaw: 13 people, 52.00%
Tooth Abscess (pus formation in tooth): 13 people, 52.00%
Spinal Osteoarthritis (joint cartilage loss in spine): 13 people, 52.00%
Chest Pain: 12 people, 48.00%
Gait Disturbance: 12 people, 48.00%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 7 people, 28.00%
Metastases To Bone (cancer spreads to bone): 5 people, 20.00%
Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 4 people, 16.00%
Osteoporosis (bones weak and more likely to break): 4 people, 16.00%
Neuralgia (pain in one or more nerves): 4 people, 16.00%
Breast Cancer: 3 people, 12.00%
Breast Cancer Metastatic: 2 people, 8.00%
Metastatic Renal Cell Carcinoma (spreadable kidney cell tumour): 2 people, 8.00%
Depression: 2 people, 8.00%
Birth Control: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

Do you take Fentanyl and have Second primary malignancy?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fentanyl:

Fentanyl (73,301 reports)

Browse all side effects of Fentanyl:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Second primary malignancy:

Second primary malignancy (579 drugs)

Browse all the conditions that are associated with Second primary malignancy:

Second primary malignancy (460 conditions)

Drugs similar to Fentanyl and Second primary malignancy :

How the study uses the data?

The study uses data from the FDA. It is based on fentanyl citrate (the active ingredients of Fentanyl) and Fentanyl (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.