Fioricet and Energy increased - a phase IV clinical study of FDA data

Summary:

Energy increased is reported as a side effect among people who take Fioricet (acetaminophen; butalbital; caffeine), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Ampyra, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Energy increased when taking Fioricet. It is created by eHealthMe based on reports of 11,479 people who have side effects when taking Fioricet from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Energy increased?

Energy increased is found to be associated with 541 drugs and 688 conditions by eHealthMe. Check the latest studies of Energy increased.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

11,479 people reported to have side effects when taking Fioricet.
Among them, 14 people (0.12%) have Energy increased.

Among these 14 people:

How long have people been on Fioricet when they have Energy increased? *

What is the gender of people who have Energy increased when taking Fioricet? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Energy increased when taking Fioricet? *

What are other drugs people take besides Fioricet? *

What are other side effects people have besides Energy increased? *

Head Injury: 5 people, 35.71%
Insomnia (sleeplessness): 4 people, 28.57%
Homicidal Ideation (thoughts about human killing another human): 3 people, 21.43%
Abnormal Behavior: 3 people, 21.43%
Aggression: 3 people, 21.43%
Memory Loss: 3 people, 21.43%
Anger: 3 people, 21.43%
Hallucinations (sensations that appear real but are created by your mind): 3 people, 21.43%
White Blood Cell Count Decreased: 2 people, 14.29%
Mania (a state of abnormally elevated or irritable mood): 2 people, 14.29%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 28.57%
Asthma: 3 people, 21.43%
Muscle Spasms (muscle contraction): 3 people, 21.43%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 2 people, 14.29%
Insomnia (sleeplessness): 2 people, 14.29%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 2 people, 14.29%
Constipation: 2 people, 14.29%
Fungal Infection: 2 people, 14.29%
Hypersensitivity: 2 people, 14.29%
Sleep Disorder: 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and have Energy increased?

- Check whether Energy increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fioricet:

Fioricet (12,423 reports)

Energy increased treatments and more:

Energy increased (7,741 reports)

How severe was Energy increased and when was it recovered:

Energy increased in Fioricet

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Energy increased and drugs with ingredients of acetaminophen; butalbital; caffeine (26 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fioricet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Energy increased:

Energy increased (541 drugs)

Browse all the conditions that are associated with Energy increased:

Energy increased (688 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Fioricet) and Fioricet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.