Fioricet and Herniated nucleus pulposus (slipped disk) - a phase IV clinical study of FDA data

Summary:

Herniated nucleus pulposus (slipped disk) is reported as a side effect among people who take Fioricet (acetaminophen; butalbital; caffeine), especially for people who are female, 40-49 old, have been taking the drug for 1 - 6 months also take Promethazine, and have Cataplexy.

The phase IV clinical study analyzes which people have Herniated nucleus pulposus (slipped disk) when taking Fioricet. It is created by eHealthMe based on reports of 11,479 people who have side effects when taking Fioricet from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Herniated nucleus pulposus (slipped disk)?

Herniated nucleus pulposus (slipped disk) is found to be associated with 583 drugs and 909 conditions by eHealthMe. Check the latest studies of Herniated nucleus pulposus (slipped disk).

On Jul, 05, 2026

11,479 people reported to have side effects when taking Fioricet.
Among them, 11 people (0.1%) have Herniated nucleus pulposus (slipped disk).

Could Fioricet cause Herniated nucleus pulposus (slipped disk)?

Among these 11 people:

How long have people been on Fioricet when they have Herniated nucleus pulposus (slipped disk)? *

What is the gender of people who have Herniated nucleus pulposus (slipped disk) when taking Fioricet? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Herniated nucleus pulposus (slipped disk) when taking Fioricet? *

What are other drugs people take besides Fioricet? *

What are other side effects people have besides Herniated nucleus pulposus (slipped disk)? *

Pain: 4 people, 36.36%
Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 18.18%
Neck Pain: 2 people, 18.18%
Head Injury: 2 people, 18.18%
Gastrointestinal Perforation (hole in the digestive tract): 2 people, 18.18%
Fibromyalgia (a long-term condition which causes pain all over the body): 2 people, 18.18%
Drug Ineffective: 2 people, 18.18%
Tremor (trembling or shaking movements in one or more parts of your body): 2 people, 18.18%
Muscle Disorder (muscle disease): 2 people, 18.18%
Muscle Tightness: 2 people, 18.18%

What are the existing conditions these people have? *

Pain: 4 people, 36.36%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 36.36%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 36.36%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 3 people, 27.27%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 27.27%
Depression: 3 people, 27.27%
Muscle Spasms (muscle contraction): 1 person, 9.09%
Drowsiness: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and have Herniated nucleus pulposus (slipped disk)?

- Check whether Herniated nucleus pulposus (slipped disk) is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fioricet:

Fioricet (12,423 reports)

Herniated nucleus pulposus (slipped disk) treatments and more:

Herniated nucleus pulposus (slipped disk) (5,608 reports)

How severe was Herniated nucleus pulposus (slipped disk) and when was it recovered:

Herniated nucleus pulposus (slipped disk) in Fioricet

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Herniated nucleus pulposus (slipped disk) and drugs with ingredients of acetaminophen; butalbital; caffeine (30 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fioricet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Herniated nucleus pulposus (slipped disk):

Herniated nucleus pulposus (slipped disk) (583 drugs)

Browse all the conditions that are associated with Herniated nucleus pulposus (slipped disk):

Herniated nucleus pulposus (slipped disk) (909 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Fioricet) and Fioricet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.