Fioricet and Sinus arrhythmia - a phase IV clinical study of FDA data

Summary:

Sinus arrhythmia is reported as a side effect among people who take Fioricet (acetaminophen; butalbital; caffeine), especially for people who are male, 40-49 old, also take Accutane, and have High blood pressure.

The phase IV clinical study analyzes which people have Sinus arrhythmia when taking Fioricet. It is created by eHealthMe based on reports of 11,479 people who have side effects when taking Fioricet from the FDA, and is updated regularly.

What is Fioricet?

Fioricet has active ingredients of acetaminophen; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 12,423 Fioricet users. Check the latest studies of Fioricet.

What is Sinus arrhythmia?

Sinus arrhythmia (a naturally occurring variation in heart rate that occurs during a breathing cycle) is found to be associated with 368 drugs and 418 conditions by eHealthMe. Check the latest studies of Sinus arrhythmia.

On Jul, 14, 2026

11,479 people reported to have side effects when taking Fioricet.
Among them, 14 people (0.12%) have Sinus arrhythmia.

Among these 14 people:

What is the gender of people who have Sinus arrhythmia when taking Fioricet? *

female: 7.14 %
male: 92.86 %

What is the age of people who have Sinus arrhythmia when taking Fioricet? *

What are other drugs people take besides Fioricet? *

Cozaar: 14 people, 100.00%
Accutane: 14 people, 100.00%
Iressa: 1 person, 7.14%
Claritin-D 24 Hour: 1 person, 7.14%
Claritin-D: 1 person, 7.14%

What are other side effects people have besides Sinus arrhythmia? *

High Blood Pressure: 14 people, 100.00%
Stress And Anxiety: 14 people, 100.00%
Inflammatory Bowel Disease: 14 people, 100.00%
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood): 14 people, 100.00%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 14 people, 100.00%
Depression: 14 people, 100.00%
Colitis (inflammation of colon): 14 people, 100.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 14 people, 100.00%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 14 people, 100.00%
Urinary Retention (the inability to completely or partially empty the bladder): 14 people, 100.00%

What are the existing conditions these people have? *

High Blood Pressure: 14 people, 100.00%
Acne Cystic (skin problems that cause pimples): 5 people, 35.71%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Fioricet and have Sinus arrhythmia?

- Check whether Sinus arrhythmia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fioricet:

Fioricet (12,423 reports)

Sinus arrhythmia treatments and more:

Sinus arrhythmia (2,228 reports)

How severe was Sinus arrhythmia and when was it recovered:

Sinus arrhythmia in Fioricet

Expand to all the drugs that have ingredients of acetaminophen; butalbital; caffeine:

Sinus arrhythmia and drugs with ingredients of acetaminophen; butalbital; caffeine (24 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fioricet:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus arrhythmia:

Sinus arrhythmia (368 drugs)

Browse all the conditions that are associated with Sinus arrhythmia:

Sinus arrhythmia (418 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; butalbital; caffeine (the active ingredients of Fioricet) and Fioricet (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.