Fiorinal and Hot flush - a phase IV clinical study of FDA data

Summary:

Hot flush is reported as a side effect among people who take Fiorinal (aspirin; butalbital; caffeine), especially for people who are 60+ old, have been taking the drug for < 1 month also take Xanax, and have Stress and anxiety.

The phase IV clinical study analyzes which people have Hot flush when taking Fiorinal. It is created by eHealthMe based on reports of 2,551 people who have side effects when taking Fiorinal from the FDA, and is updated regularly.

What is Fiorinal?

Fiorinal has active ingredients of aspirin; butalbital; caffeine. It is often used in migraine. eHealthMe is studying from 2,714 Fiorinal users. Check the latest studies of Fiorinal.

What is Hot flush?

Hot flush (sudden feelings of heat) is found to be associated with 1,767 drugs and 2,347 conditions by eHealthMe. Check the latest studies of Hot flush.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 05, 2026

2,551 people reported to have side effects when taking Fiorinal.
Among them, 14 people (0.55%) have Hot flush.

Among these 14 people:

How long have people been on Fiorinal when they have Hot flush? *

What is the age of people who have Hot flush when taking Fiorinal? *

What are other drugs people take besides Fiorinal? *

Xanax: 4 people, 28.57%
Propoxyphene Hydrochloride: 3 people, 21.43%
Niacin: 3 people, 21.43%
Naproxen: 3 people, 21.43%
Dilantin: 3 people, 21.43%
Diazepam: 3 people, 21.43%
Synthroid: 3 people, 21.43%
Myrbetriq: 2 people, 14.29%
Provigil: 2 people, 14.29%
Copaxone: 2 people, 14.29%

What are other side effects people have besides Hot flush? *

Pain In Extremity: 6 people, 42.86%
Weight Decreased: 5 people, 35.71%
Stress And Anxiety: 4 people, 28.57%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 4 people, 28.57%
Hyperhidrosis (abnormally increased sweating): 3 people, 21.43%
Mobility Decreased (ability to move is reduced): 3 people, 21.43%
Meniere's Disease (a disorder of the inner ear that can affect hearing and balance to a varying degree): 3 people, 21.43%
Blood Glucose Abnormal: 3 people, 21.43%
Oedema Peripheral (superficial swelling): 3 people, 21.43%
Insomnia (sleeplessness): 3 people, 21.43%

What are the existing conditions these people have? *

Stress And Anxiety: 4 people, 28.57%
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve): 3 people, 21.43%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 14.29%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 2 people, 14.29%
Rickets (softening of bones): 1 person, 7.14%
Pain: 1 person, 7.14%
Breast Cancer: 1 person, 7.14%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 7.14%
Cough: 1 person, 7.14%
Dehydroepiandrosterone Decreased: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Fiorinal and have Hot flush?

- Check whether Hot flush is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fiorinal:

Fiorinal (2,714 reports)

Hot flush treatments and more:

Hot flush (91,208 reports)

Browse all side effects of Fiorinal:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hot flush:

Hot flush (1,767 drugs)

Browse all the conditions that are associated with Hot flush:

Hot flush (2,347 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on aspirin; butalbital; caffeine (the active ingredients of Fiorinal) and Fiorinal (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.