Firdapse and Hyperhidrosis - a phase IV clinical study of FDA data

Summary:

Hyperhidrosis is reported as a side effect among people who take Firdapse (amifampridine), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Mestinon, and have Lambert-eaton syndrome.

The phase IV clinical study analyzes which people have Hyperhidrosis when taking Firdapse. It is created by eHealthMe based on reports of 2,110 people who have side effects when taking Firdapse from the FDA, and is updated regularly.

What is Firdapse?

Firdapse has active ingredients of amifampridine. eHealthMe is studying from 2,112 Firdapse users. Check the latest studies of Firdapse.

What is Hyperhidrosis?

Hyperhidrosis (abnormally increased sweating) is found to be associated with 2,558 drugs and 3,545 conditions by eHealthMe. Check the latest studies of Hyperhidrosis.

On Jun, 18, 2026

2,110 people reported to have side effects when taking Firdapse.
Among them, 37 people (1.75%) have Hyperhidrosis.

Among these 37 people:

How long have people been on Firdapse when they have Hyperhidrosis? *

What is the gender of people who have Hyperhidrosis when taking Firdapse? *

female: 56.76 %
male: 43.24 %

What is the age of people who have Hyperhidrosis when taking Firdapse? *

What are other drugs people take besides Firdapse? *

What are other side effects people have besides Hyperhidrosis? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 18 people, 48.65%
Hypoaesthesia (reduced sense of touch or sensation): 13 people, 35.14%
Nausea (feeling of having an urge to vomit): 12 people, 32.43%
Gait Disturbance: 11 people, 29.73%
Paraesthesia Oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect): 11 people, 29.73%
Headache (pain in head): 10 people, 27.03%
Weakness: 10 people, 27.03%
Drug Ineffective: 9 people, 24.32%
Fatigue (feeling of tiredness): 9 people, 24.32%
Feeling Cold: 7 people, 18.92%

What are the existing conditions these people have? *

Lambert-Eaton Syndrome (this means your immune system mistakenly targets healthy cells and tissues in the body): 31 people, 83.78%
Myasthenia Gravis (a chronic condition that causes muscles to tire and weaken easily): 5 people, 13.51%
Tumor: 2 people, 5.41%
Stiff Person Syndrome: 2 people, 5.41%
Muscle Spasms (muscle contraction): 2 people, 5.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 5.41%
Chronic Inflammatory Demyelinating Polyradiculoneuropathy (long lasting infection of nerves outside brain and spinal cord): 2 people, 5.41%
Stress And Anxiety: 1 person, 2.70%
Respiratory Muscle Weakness: 1 person, 2.70%
Pain: 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Firdapse and have Hyperhidrosis?

- Check whether Hyperhidrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Firdapse:

Firdapse (2,112 reports)

Hyperhidrosis treatments and more:

Hyperhidrosis (147,206 reports)

Browse all side effects of Firdapse:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperhidrosis:

Hyperhidrosis (2,558 drugs)

Browse all the conditions that are associated with Hyperhidrosis:

Hyperhidrosis (3,545 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amifampridine (the active ingredients of Firdapse) and Firdapse (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.