Flolan and Circulatory collapse - a phase IV clinical study of FDA data

Summary:

Circulatory collapse is reported as a side effect among people who take Flolan (epoprostenol sodium), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Sildenafil Citrate, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Circulatory collapse when taking Flolan. It is created by eHealthMe based on reports of 10,044 people who have side effects when taking Flolan from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Circulatory collapse?

Circulatory collapse is found to be associated with 1,122 drugs and 1,403 conditions by eHealthMe. Check the latest studies of Circulatory collapse.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

10,044 people reported to have side effects when taking Flolan.
Among them, 17 people (0.17%) have Circulatory collapse.

Could Flolan cause Circulatory collapse?

Among these 17 people:

How long have people been on Flolan when they have Circulatory collapse? *

What is the gender of people who have Circulatory collapse when taking Flolan? *

female: 62.5 %
male: 37.5 %

What is the age of people who have Circulatory collapse when taking Flolan? *

What are other drugs people take besides Flolan? *

What are other side effects people have besides Circulatory collapse? *

Malaise (a feeling of general discomfort or uneasiness): 6 people, 35.29%
Dyspnea (difficult or laboured breathing): 6 people, 35.29%
Cardiac Failure: 6 people, 35.29%
Cardiac Arrest: 6 people, 35.29%
Thrombocytopenia (decrease of platelets in blood): 6 people, 35.29%
Fatigue (feeling of tiredness): 5 people, 29.41%
Death: 5 people, 29.41%
Hypotension (abnormally low blood pressure): 4 people, 23.53%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 23.53%
Pulmonary Haemorrhage (acute bleeding from the lung): 4 people, 23.53%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 52.94%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 1 person, 5.88%
Polymyositis (inflammatory muscle disease that causes weakness of the skeletal muscles): 1 person, 5.88%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 5.88%
High Blood Pressure: 1 person, 5.88%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.88%
Cardiomyopathy (weakening of the heart muscle): 1 person, 5.88%
Cardiac Failure: 1 person, 5.88%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Flolan and have Circulatory collapse?

- Check whether Circulatory collapse is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flolan:

Flolan (10,067 reports)

Browse all side effects of Flolan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Circulatory collapse:

Circulatory collapse (1,122 drugs)

Browse all the conditions that are associated with Circulatory collapse:

Circulatory collapse (1,403 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on epoprostenol sodium (the active ingredients of Flolan) and Flolan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.