Flolan and Gallbladder attack - a phase IV clinical study of FDA data

Summary:

Gallbladder attack is reported as a side effect among people who take Flolan (epoprostenol sodium), especially for people who are female, 50-59 old, also take Coumadin, and have Pulmonary hypertension.

The phase IV clinical study analyzes which people have Gallbladder attack when taking Flolan. It is created by eHealthMe based on reports of 10,044 people who have side effects when taking Flolan from the FDA, and is updated regularly.

What is Flolan?

Flolan has active ingredients of epoprostenol sodium. eHealthMe is studying from 10,067 Flolan users. Check the latest studies of Flolan.

What is Gallbladder attack?

Gallbladder attack (gallstones, gallbladder disease and gallbladder pain) is found to be associated with 652 drugs and 976 conditions by eHealthMe. Check the latest studies of Gallbladder attack.

On Oct, 19, 2025

10,044 people reported to have side effects when taking Flolan.
Among them, 8 people (0.08%) have Gallbladder attack.

Among these 8 people:

What is the gender of people who have Gallbladder attack when taking Flolan? *

female: 100 %
male: 0.0 %

What is the age of people who have Gallbladder attack when taking Flolan? *

What are other drugs people take besides Flolan? *

What are other side effects people have besides Gallbladder attack? *

Thrombocytopenia (decrease of platelets in blood): 4 people, 50.00%
Skin Blushing/flushing (a sudden reddening of the face, neck): 4 people, 50.00%
Fatigue (feeling of tiredness): 3 people, 37.50%
Hepatic Failure (liver failure): 3 people, 37.50%
Nausea (feeling of having an urge to vomit): 3 people, 37.50%
Cholecystitis (infection of gallbladder): 3 people, 37.50%
Cholestasis (a condition where bile cannot flow from the liver to the duodenum): 3 people, 37.50%
Dehydration (dryness resulting from the removal of water): 3 people, 37.50%
Diarrhea: 3 people, 37.50%
Autoimmune Hepatitis: 3 people, 37.50%

What are the existing conditions these people have? *

Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 50.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 2 people, 25.00%

* Approximation only. Some reports may have incomplete information.

Do you take Flolan and have Gallbladder attack?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Flolan:

Flolan (10,067 reports)

Browse all side effects of Flolan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Gallbladder attack:

Gallbladder attack (652 drugs)

Browse all the conditions that are associated with Gallbladder attack:

Gallbladder attack (976 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on epoprostenol sodium (the active ingredients of Flolan) and Flolan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.