Florinef and Anhedonia - a phase IV clinical study of FDA data

Summary:

Anhedonia is reported as a side effect among people who take Florinef (fludrocortisone acetate), especially for people who are male, 50-59 old, have been taking the drug for 1 - 2 years also take Zometa, and have Pain.

The phase IV clinical study analyzes which people have Anhedonia when taking Florinef. It is created by eHealthMe based on reports of 3,634 people who have side effects when taking Florinef from the FDA, and is updated regularly.

What is Florinef?

Florinef has active ingredients of fludrocortisone acetate. It is often used in addison's disease. eHealthMe is studying from 3,834 Florinef users. Check the latest studies of Florinef.

What is Anhedonia?

Anhedonia (inability to experience pleasure from activities usually found enjoyable) is found to be associated with 1,506 drugs and 1,282 conditions by eHealthMe. Check the latest studies of Anhedonia.

On Aug, 06, 2026

3,634 people reported to have side effects when taking Florinef.
Among them, 45 people (1.24%) have Anhedonia.

Among these 45 people:

How long have people been on Florinef when they have Anhedonia? *

What is the gender of people who have Anhedonia when taking Florinef? *

female: 42.22 %
male: 57.78 %

What is the age of people who have Anhedonia when taking Florinef? *

What are other drugs people take besides Florinef? *

Zometa: 31 people, 68.89%
Midodrine Hydrochloride: 23 people, 51.11%
Vicodin: 21 people, 46.67%
Xanax: 20 people, 44.44%
Ibuprofen: 17 people, 37.78%
Zoloft: 16 people, 35.56%
Seroquel: 16 people, 35.56%
Hyzaar: 16 people, 35.56%
Lexapro: 16 people, 35.56%
Lipitor: 16 people, 35.56%

What are other side effects people have besides Anhedonia? *

Pain: 45 people, 100.00%
Stress And Anxiety: 36 people, 80.00%
Injury: 35 people, 77.78%
Joint Pain: 35 people, 77.78%
Back Pain: 32 people, 71.11%
Diarrhea: 31 people, 68.89%
Metastases To Bone (cancer spreads to bone): 31 people, 68.89%
Emotional Distress: 29 people, 64.44%
Hyperlipidaemia (presence of excess lipids in the blood): 27 people, 60.00%
Intervertebral Disc Degeneration (spinal disc degeneration): 27 people, 60.00%

What are the existing conditions these people have? *

Pain: 17 people, 37.78%
Prostate Cancer: 16 people, 35.56%
Bone Density Abnormal: 15 people, 33.33%
Neoplasm Malignant (cancer tumour): 4 people, 8.89%
High Blood Pressure: 3 people, 6.67%
Osteoporosis (bones weak and more likely to break): 3 people, 6.67%
Stress And Anxiety: 3 people, 6.67%
Viral Infection: 2 people, 4.44%
Dizziness: 2 people, 4.44%
High Blood Cholesterol: 2 people, 4.44%

* Approximation only. Some reports may have incomplete information.

Do you take Florinef and have Anhedonia?

- Check whether Anhedonia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Florinef:

Florinef (3,834 reports)

Anhedonia treatments and more:

Anhedonia (51,944 reports)

Browse all side effects of Florinef:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Anhedonia:

Anhedonia (1,506 drugs)

Browse all the conditions that are associated with Anhedonia:

Anhedonia (1,282 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fludrocortisone acetate (the active ingredients of Florinef) and Florinef (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.