Fluconazole and Disseminated cryptococcosis - a phase IV clinical study of FDA data

Summary:

Disseminated cryptococcosis is reported as a side effect among people who take Fluconazole (fluconazole), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Stavudine, and have Cryptococcosis.

The phase IV clinical study analyzes which people have Disseminated cryptococcosis when taking Fluconazole. It is created by eHealthMe based on reports of 69,269 people who have side effects when taking Fluconazole from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Disseminated cryptococcosis?

Disseminated cryptococcosis (one of the acquired immune deficiency syndrome defining criteria and the most common cause of life threatening meningitis) is found to be associated with 60 drugs and 95 conditions by eHealthMe. Check the latest studies of Disseminated cryptococcosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 28, 2026

69,269 people reported to have side effects when taking Fluconazole.
Among them, 49 people (0.07%) have Disseminated cryptococcosis.

Could Fluconazole cause Disseminated cryptococcosis?

Among these 49 people:

How long have people been on Fluconazole when they have Disseminated cryptococcosis? *

What is the gender of people who have Disseminated cryptococcosis when taking Fluconazole? *

female: 26.09 %
male: 73.91 %

What is the age of people who have Disseminated cryptococcosis when taking Fluconazole? *

What are other drugs people take besides Fluconazole? *

What are other side effects people have besides Disseminated cryptococcosis? *

Meningitis Cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 18 people, 36.73%
Rashes (redness): 12 people, 24.49%
Weakness: 9 people, 18.37%
Headache (pain in head): 9 people, 18.37%
Immune Reconstitution Syndrome (immune recovery syndrome): 9 people, 18.37%
Grand Mal Convulsion (a type of generalized seizure that affects the entire brain): 8 people, 16.33%
Drug Ineffective: 7 people, 14.29%
Neck Pain: 6 people, 12.24%
Intracranial Pressure Increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid): 6 people, 12.24%
Back Pain: 6 people, 12.24%

What are the existing conditions these people have? *

Hiv Infection: 12 people, 24.49%
Cryptococcosis (potentially fatal fungal disease): 12 people, 24.49%
Meningitis Cryptococcal (bacterial inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 9 people, 18.37%
Pneumonia: 6 people, 12.24%
Lupus Nephritis (a chronic inflammatory autoimmune disorder that may affect kidney tissue): 4 people, 8.16%
Cellulitis (infection under the skin): 4 people, 8.16%
High Blood Pressure: 4 people, 8.16%
Rashes (redness): 3 people, 6.12%
Nausea (feeling of having an urge to vomit): 3 people, 6.12%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

Do you take Fluconazole and have Disseminated cryptococcosis?

- Check whether Disseminated cryptococcosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluconazole:

Fluconazole (70,481 reports)

Browse all side effects of Fluconazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Disseminated cryptococcosis:

Disseminated cryptococcosis (60 drugs)

Browse all the conditions that are associated with Disseminated cryptococcosis:

Disseminated cryptococcosis (95 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluconazole (the active ingredients of Fluconazole) and Fluconazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.