Fluconazole and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Fluconazole (fluconazole), especially for people who are female, 50-59 old, also take Revlimid, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Fluconazole. It is created by eHealthMe based on reports of 69,269 people who have side effects when taking Fluconazole from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 775 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

69,269 people reported to have side effects when taking Fluconazole.
Among them, 51 people (0.07%) have Hyperkeratosis.

Among these 51 people:

What is the gender of people who have Hyperkeratosis when taking Fluconazole? *

female: 78 %
male: 22 %

What is the age of people who have Hyperkeratosis when taking Fluconazole? *

What are other drugs people take besides Fluconazole? *

Zometa: 26 people, 50.98%
Revlimid: 26 people, 50.98%
Chlorhexidine Gluconate: 23 people, 45.10%
Ativan: 23 people, 45.10%
Metronidazole: 22 people, 43.14%
Hydrochlorothiazide: 22 people, 43.14%
Acyclovir: 21 people, 41.18%
Zoloft: 18 people, 35.29%
Neupogen: 17 people, 33.33%
Lipitor: 17 people, 33.33%

What are other side effects people have besides Hyperkeratosis? *

Pain: 39 people, 76.47%
Stress And Anxiety: 31 people, 60.78%
Spinal Osteoarthritis (joint cartilage loss in spine): 29 people, 56.86%
Emotional Distress: 28 people, 54.90%
Diarrhea: 28 people, 54.90%
Pain In Jaw: 27 people, 52.94%
High Blood Pressure: 27 people, 52.94%
Osteonecrosis Of Jaw (death of bone of jaw): 27 people, 52.94%
Nausea (feeling of having an urge to vomit): 26 people, 50.98%
Weakness: 25 people, 49.02%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 28 people, 54.90%
High Blood Pressure: 15 people, 29.41%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 15 people, 29.41%
Fatigue (feeling of tiredness): 14 people, 27.45%
Infection: 2 people, 3.92%
Meningitis Coccidioides (fungal inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges): 2 people, 3.92%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 3.92%
Colon Cancer: 2 people, 3.92%
Chronic Lymphocytic Leukaemia Stage 4 (blood cell cancer with too few blood platelets), with or without anaemia, enlarged lymph nodes, spleen, or liver): 2 people, 3.92%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 3.92%

* Approximation only. Some reports may have incomplete information.

Do you take Fluconazole and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluconazole:

Fluconazole (70,481 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Fluconazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (775 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluconazole (the active ingredients of Fluconazole) and Fluconazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.