Fluconazole and Small intestinal perforation - a phase IV clinical study of FDA data

Summary:

Small intestinal perforation is reported as a side effect among people who take Fluconazole (fluconazole), especially for people who are male, 20-29 old, have been taking the drug for < 1 month also take Cyclophosphamide, and have Burkitt's lymphoma.

The phase IV clinical study analyzes which people have Small intestinal perforation when taking Fluconazole. It is created by eHealthMe based on reports of 69,269 people who have side effects when taking Fluconazole from the FDA, and is updated regularly.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

What is Small intestinal perforation?

Small intestinal perforation (hole in small intestine) is found to be associated with 232 drugs and 424 conditions by eHealthMe. Check the latest studies of Small intestinal perforation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

69,269 people reported to have side effects when taking Fluconazole.
Among them, 36 people (0.05%) have Small intestinal perforation.

Could Fluconazole cause Small intestinal perforation?

Among these 36 people:

How long have people been on Fluconazole when they have Small intestinal perforation? *

What is the gender of people who have Small intestinal perforation when taking Fluconazole? *

female: 27.27 %
male: 72.73 %

What is the age of people who have Small intestinal perforation when taking Fluconazole? *

What are other drugs people take besides Fluconazole? *

What are other side effects people have besides Small intestinal perforation? *

Blood Lactate Dehydrogenase Increased: 8 people, 22.22%
Disease Progression: 7 people, 19.44%
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs): 6 people, 16.67%
Anaemia (lack of blood): 3 people, 8.33%
Febrile Neutropenia (fever with reduced white blood cells): 3 people, 8.33%
Rashes (redness): 3 people, 8.33%
White Blood Cell Count Increased: 2 people, 5.56%
Hypokalemia (low potassium): 2 people, 5.56%
Head Injury: 2 people, 5.56%
Weight Decreased: 2 people, 5.56%

What are the existing conditions these people have? *

Burkitt's Lymphoma (cancer of the lymphatic system): 8 people, 22.22%
Cytokine Release Syndrome (immediate complication occurring with the use of anti-t cell antibody infusions): 5 people, 13.89%
Diffuse Large B-Cell Lymphoma Stage Iv (cancer of b cells, a type of white blood cell-stage iv): 5 people, 13.89%
Abdominal Infection: 3 people, 8.33%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 8.33%
Oral Candidiasis (fungal infection of mouth): 3 people, 8.33%
Infusion Related Reaction: 2 people, 5.56%
Abscess (pus): 2 people, 5.56%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 2 people, 5.56%
Clostridium Test Positive: 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Fluconazole and have Small intestinal perforation?

- Check whether Small intestinal perforation is associated with a drug or a condition
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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluconazole:

Fluconazole (70,481 reports)

Browse all side effects of Fluconazole:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Small intestinal perforation:

Small intestinal perforation (232 drugs)

Browse all the conditions that are associated with Small intestinal perforation:

Small intestinal perforation (424 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluconazole (the active ingredients of Fluconazole) and Fluconazole (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.