Fluorouracil and K-ras gene mutation - a phase IV clinical study of FDA data

Summary:

K-ras gene mutation is reported as a side effect among people who take Fluorouracil (fluorouracil), especially for people who are female, 60+ old, also take Erbitux, and have Colorectal cancer metastatic.

The phase IV clinical study analyzes which people have K-ras gene mutation when taking Fluorouracil. It is created by eHealthMe based on reports of 96,940 people who have side effects when taking Fluorouracil from the FDA, and is updated regularly.

What is Fluorouracil?

Fluorouracil has active ingredients of fluorouracil. It is often used in colon cancer metastatic. eHealthMe is studying from 97,087 Fluorouracil users. Check the latest studies of Fluorouracil.

What is K-ras gene mutation?

K-ras gene mutation is found to be associated with 4 drugs and 21 conditions by eHealthMe. Check the latest studies of K-ras gene mutation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 23, 2026

96,940 people reported to have side effects when taking Fluorouracil.
Among them, 12 people (0.01%) have K-ras gene mutation.

Could Fluorouracil cause K-ras gene mutation?

Among these 12 people:

What is the gender of people who have K-ras gene mutation when taking Fluorouracil? *

female: 58.33 %
male: 41.67 %

What is the age of people who have K-ras gene mutation when taking Fluorouracil? *

What are other drugs people take besides Fluorouracil? *

Erbitux: 2 people, 16.67%
Zaltrap: 1 person, 8.33%
Xeloda: 1 person, 8.33%

What are other side effects people have besides K-ras gene mutation? *

Multiple-Drug Resistance: 3 people, 25.00%
Drug Hypersensitivity: 3 people, 25.00%
Tumor Marker Increased: 2 people, 16.67%
Enterovesical Fistula: 2 people, 16.67%
Haematotoxicity (toxins that destroy red blood cells): 2 people, 16.67%
Malignant Neoplasm Progression (cancer tumour came back): 2 people, 16.67%
Metastases To Lung (cancer spreads to lung): 2 people, 16.67%
Abdominal Wall Abscess (abdominal wall infection): 2 people, 16.67%
Neutropenic Sepsis (whole body infection is caused by a condition in which the number of white blood cells (called neutrophils) in the blood is low. neutrophils help the body to fight infection): 1 person, 8.33%
Pigmentation Disorder (disturbances of human skin colour): 1 person, 8.33%

What are the existing conditions these people have? *

Colorectal Cancer Metastatic (cancer of colon and rectal spreads to other parts): 4 people, 33.33%
Metastatic Neoplasm (spreadable cancer tumour): 3 people, 25.00%
Colon Cancer: 2 people, 16.67%
Rectal Cancer Metastatic (cancer of rectum spreads to other): 1 person, 8.33%
Rectal Cancer (cancer of rectum): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Fluorouracil and have K-ras gene mutation?

- Check whether K-ras gene mutation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluorouracil:

Fluorouracil (97,087 reports)

Browse all side effects of Fluorouracil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with K-ras gene mutation:

K-ras gene mutation (4 drugs)

Browse all the conditions that are associated with K-ras gene mutation:

K-ras gene mutation (21 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluorouracil (the active ingredients of Fluorouracil) and Fluorouracil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.