Fluorouracil and Mediastinitis - a phase IV clinical study of FDA data

Summary:

Mediastinitis is reported as a side effect among people who take Fluorouracil (fluorouracil), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Cisplatin, and have Oesophageal carcinoma.

The phase IV clinical study analyzes which people have Mediastinitis when taking Fluorouracil. It is created by eHealthMe based on reports of 96,940 people who have side effects when taking Fluorouracil from the FDA, and is updated regularly.

What is Fluorouracil?

Fluorouracil has active ingredients of fluorouracil. It is often used in colon cancer metastatic. eHealthMe is studying from 97,087 Fluorouracil users. Check the latest studies of Fluorouracil.

What is Mediastinitis?

Mediastinitis (inflammation of the tissues in the mid-chest) is found to be associated with 96 drugs and 230 conditions by eHealthMe. Check the latest studies of Mediastinitis.

On Jul, 26, 2026

96,940 people reported to have side effects when taking Fluorouracil.
Among them, 23 people (0.02%) have Mediastinitis.

Among these 23 people:

How long have people been on Fluorouracil when they have Mediastinitis? *

What is the gender of people who have Mediastinitis when taking Fluorouracil? *

female: 11.76 %
male: 88.24 %

What is the age of people who have Mediastinitis when taking Fluorouracil? *

What are other drugs people take besides Fluorouracil? *

Cisplatin: 7 people, 30.43%
Oxaliplatin: 5 people, 21.74%
Pantoprazole Sodium: 3 people, 13.04%
Opdivo: 3 people, 13.04%
Prednisolone: 2 people, 8.70%
Ondansetron: 2 people, 8.70%
Metoclopramide Hydrochloride: 2 people, 8.70%
Leucovorin Calcium: 2 people, 8.70%
Taxotere: 1 person, 4.35%
Fentanyl: 1 person, 4.35%

What are other side effects people have besides Mediastinitis? *

Oesophageal Perforation (hole in oesophagus): 7 people, 30.43%
Pneumonia: 5 people, 21.74%
Abscess (pus): 4 people, 17.39%
Chest Pain: 4 people, 17.39%
Nausea (feeling of having an urge to vomit): 4 people, 17.39%
Fever: 4 people, 17.39%
Pleural Effusion (water on the lungs): 4 people, 17.39%
Oesophagitis (inflammation of oesophagus): 3 people, 13.04%
Malaise (a feeling of general discomfort or uneasiness): 3 people, 13.04%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 3 people, 13.04%

What are the existing conditions these people have? *

Oesophageal Carcinoma (cancer tumour of oesophagus): 8 people, 34.78%
Oesophageal Squamous Cell Carcinoma (cancer that begins in flat cells lining the oesophagus): 5 people, 21.74%
Oesophageal Adenocarcinoma (a cancer tumour of an epithelium in oesophagus): 4 people, 17.39%
Squamous Cell Carcinoma (a cancer of a kind of epithelial cell): 3 people, 13.04%
Metastases To Lung (cancer spreads to lung): 3 people, 13.04%
Gastric Cancer Stage I (the tumour has invaded only the sub mucosa. cancer cells may be found in up to 6 lymph nodes): 3 people, 13.04%
Oesophageal Cancer Metastatic (cancer of oesophagues spreads to other part): 2 people, 8.70%
Oesophageal Squamous Cell Carcinoma Stage Iv (the cancer has spread to distant lymph nodes or other sites): 1 person, 4.35%

* Approximation only. Some reports may have incomplete information.

Do you take Fluorouracil and have Mediastinitis?

- Check whether Mediastinitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluorouracil:

Fluorouracil (97,087 reports)

Mediastinitis treatments and more:

Mediastinitis (1,212 reports)

Browse all side effects of Fluorouracil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mediastinitis:

Mediastinitis (96 drugs)

Browse all the conditions that are associated with Mediastinitis:

Mediastinitis (230 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluorouracil (the active ingredients of Fluorouracil) and Fluorouracil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.