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Fluorouracil and Oesophageal squamous cell carcinoma - a phase IV clinical study of FDA data

Summary:

Oesophageal squamous cell carcinoma is reported as a side effect among people who take Fluorouracil (fluorouracil), especially for people who are male, 50-59 old, have been taking the drug for 1 - 6 months also take Cisplatin, and have Oesophageal carcinoma.

The phase IV clinical study analyzes which people have Oesophageal squamous cell carcinoma when taking Fluorouracil. It is created by eHealthMe based on reports of 96,940 people who have side effects when taking Fluorouracil from the FDA, and is updated regularly.

What is Fluorouracil?

Fluorouracil has active ingredients of fluorouracil. It is often used in colon cancer metastatic. eHealthMe is studying from 97,087 Fluorouracil users. Check the latest studies of Fluorouracil.

What is Oesophageal squamous cell carcinoma?

Oesophageal squamous cell carcinoma (cancer that begins in flat cells lining the oesophagus) is found to be associated with 38 drugs and 125 conditions by eHealthMe. Check the latest studies of Oesophageal squamous cell carcinoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 15, 2026

96,940 people reported to have side effects when taking Fluorouracil.
Among them, 16 people (0.02%) have Oesophageal squamous cell carcinoma.

Could Fluorouracil cause Oesophageal squamous cell carcinoma?

Among these 16 people:

How long have people been on Fluorouracil when they have Oesophageal squamous cell carcinoma? *

  • < 1 month: 0.0 %
  • 1 - 6 months: 100 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Oesophageal squamous cell carcinoma when taking Fluorouracil? *

  • female: 8.33 %
  • male: 91.67 %

What is the age of people who have Oesophageal squamous cell carcinoma when taking Fluorouracil? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 0.0 %
  • 40-49: 0.0 %
  • 50-59: 81.82 %
  • 60+: 18.18 %

What are other drugs people take besides Fluorouracil? *

  1. Tiotropium Bromide: 4 people, 25.00%
  2. Promethazine: 4 people, 25.00%
  3. Cisplatin: 4 people, 25.00%
  4. Metformin: 3 people, 18.75%
  5. Docetaxel: 3 people, 18.75%
  6. Ciprofloxacin: 2 people, 12.50%
  7. Omeprazole: 1 person, 6.25%
  8. Humira: 1 person, 6.25%
  9. Depo-Medrol: 1 person, 6.25%

What are other side effects people have besides Oesophageal squamous cell carcinoma? *

  1. White Blood Cell Count Decreased: 5 people, 31.25%
  2. White Blood Cell Count Increased: 4 people, 25.00%
  3. Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 25.00%
  4. Leukopenia (less number of white blood cells in blood): 4 people, 25.00%
  5. Malignant Neoplasm Progression (cancer tumour came back): 4 people, 25.00%
  6. Neutrophil Count Decreased (less than normal number of neutrophil a type of blood cell): 4 people, 25.00%
  7. Neutrophil Count Increased (excess than normal number of neutrophil a type of blood cell): 4 people, 25.00%
  8. Thrombocytopenia (decrease of platelets in blood): 4 people, 25.00%
  9. Swallowing Difficulty: 2 people, 12.50%
  10. Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue): 2 people, 12.50%

What are the existing conditions these people have? *

  1. Oesophageal Carcinoma (cancer tumour of oesophagus): 7 people, 43.75%
  2. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 4 people, 25.00%
  3. High Blood Pressure: 4 people, 25.00%
  4. High Blood Cholesterol: 4 people, 25.00%
  5. Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 4 people, 25.00%
  6. Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 1 person, 6.25%
  7. Gastric Disorder (disease of stomach): 1 person, 6.25%
  8. Breast Cancer: 1 person, 6.25%
  9. Bladder Outlet Obstruction (urological condition where the urine flow from the urinary bladder through the urethra is impeded): 1 person, 6.25%
  10. Adenocarcinoma (malignant tumour formed from glandular structures in epithelial tissue): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Fluorouracil and have Oesophageal squamous cell carcinoma?

- Check whether Oesophageal squamous cell carcinoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluorouracil:

Oesophageal squamous cell carcinoma treatments and more:

How severe was Oesophageal squamous cell carcinoma and when was it recovered:

Expand to all the drugs that have ingredients of fluorouracil:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fluorouracil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Oesophageal squamous cell carcinoma:

Browse all the conditions that are associated with Oesophageal squamous cell carcinoma:

How the study uses the data?

The study uses data from the FDA. It is based on fluorouracil (the active ingredients of Fluorouracil) and Fluorouracil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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