Fluorouracil and Type iv hypersensitivity reaction - a phase IV clinical study of FDA data

Summary:

Type iv hypersensitivity reaction is reported as a side effect among people who take Fluorouracil (fluorouracil), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Oxaliplatin, and have Colon cancer.

The phase IV clinical study analyzes which people have Type iv hypersensitivity reaction when taking Fluorouracil. It is created by eHealthMe based on reports of 96,940 people who have side effects when taking Fluorouracil from the FDA, and is updated regularly.

What is Fluorouracil?

Fluorouracil has active ingredients of fluorouracil. It is often used in colon cancer metastatic. eHealthMe is studying from 97,087 Fluorouracil users. Check the latest studies of Fluorouracil.

What is Type iv hypersensitivity reaction?

Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop) is found to be associated with 196 drugs and 415 conditions by eHealthMe. Check the latest studies of Type iv hypersensitivity reaction.

On Jul, 13, 2026

96,940 people reported to have side effects when taking Fluorouracil.
Among them, 28 people (0.03%) have Type iv hypersensitivity reaction.

Could Fluorouracil cause Type iv hypersensitivity reaction?

Among these 28 people:

How long have people been on Fluorouracil when they have Type iv hypersensitivity reaction? *

What is the gender of people who have Type iv hypersensitivity reaction when taking Fluorouracil? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Type iv hypersensitivity reaction when taking Fluorouracil? *

What are other drugs people take besides Fluorouracil? *

What are other side effects people have besides Type iv hypersensitivity reaction? *

Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 17.86%
Neuropathy Peripheral (surface nerve damage): 4 people, 14.29%
Rashes (redness): 3 people, 10.71%
Rash Erythematous (redness of the skin): 3 people, 10.71%
Leukopenia (less number of white blood cells in blood): 3 people, 10.71%
Nausea (feeling of having an urge to vomit): 3 people, 10.71%
Coughing Up Blood: 3 people, 10.71%
Ards (Acute Respiratory Distress Syndrome) (sudden failure of the respiratory (breathing) system): 3 people, 10.71%
Weakness: 2 people, 7.14%
Skin Blushing/flushing (a sudden reddening of the face, neck): 2 people, 7.14%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 4 people, 14.29%
Colon Cancer: 4 people, 14.29%
Neoplasm Malignant (cancer tumour): 2 people, 7.14%
Metastases To Liver (cancer spreads to liver): 2 people, 7.14%
Oesophageal Adenocarcinoma Stage Iv (cancer has spread to other parts of the body): 1 person, 3.57%
Metastases To Lymph Nodes (cancer spreads to lymph node): 1 person, 3.57%
Colon Cancer Stage Iv: 1 person, 3.57%
Colon Cancer Stage Ii: 1 person, 3.57%
Chronic Renal Failure (kidney failure): 1 person, 3.57%
Cholangiocarcinoma (a cancer that forms glands or secretes significant amounts of mucins): 1 person, 3.57%

* Approximation only. Some reports may have incomplete information.

Do you take Fluorouracil and have Type iv hypersensitivity reaction?

- Check whether Type iv hypersensitivity reaction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluorouracil:

Fluorouracil (97,087 reports)

Browse all side effects of Fluorouracil:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Type iv hypersensitivity reaction:

Type iv hypersensitivity reaction (196 drugs)

Browse all the conditions that are associated with Type iv hypersensitivity reaction:

Type iv hypersensitivity reaction (415 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluorouracil (the active ingredients of Fluorouracil) and Fluorouracil (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.