Fluoxetine hydrochloride and Hyperreflexia - a phase IV clinical study of FDA data

Summary:

Hyperreflexia is reported as a side effect among people who take Fluoxetine hydrochloride (fluoxetine hydrochloride), especially for people who are female, 10-19 old, have been taking the drug for < 1 month also take Hydroxyzine, and have Insomnia.

The phase IV clinical study analyzes which people have Hyperreflexia when taking Fluoxetine hydrochloride. It is created by eHealthMe based on reports of 11,975 people who have side effects when taking Fluoxetine hydrochloride from the FDA, and is updated regularly.

What is Fluoxetine hydrochloride?

Fluoxetine hydrochloride has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 13,381 Fluoxetine hydrochloride users. Check the latest studies of Fluoxetine hydrochloride.

What is Hyperreflexia?

Hyperreflexia (overactive or over responsive reflexes) is found to be associated with 416 drugs and 652 conditions by eHealthMe. Check the latest studies of Hyperreflexia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

11,975 people reported to have side effects when taking Fluoxetine hydrochloride.
Among them, 25 people (0.21%) have Hyperreflexia.

Could Fluoxetine hydrochloride cause Hyperreflexia?

Among these 25 people:

How long have people been on Fluoxetine hydrochloride when they have Hyperreflexia? *

What is the gender of people who have Hyperreflexia when taking Fluoxetine hydrochloride? *

female: 53.33 %
male: 46.67 %

What is the age of people who have Hyperreflexia when taking Fluoxetine hydrochloride? *

What are other drugs people take besides Fluoxetine hydrochloride? *

What are other side effects people have besides Hyperreflexia? *

Serotonin Syndrome (occurs when two drugs that affect the body's level of serotonin are taken together at the same time): 13 people, 52.00%
Clonus (series of involuntary, rhythmic, muscular contractions and relaxations): 12 people, 48.00%
Agitation (state of anxiety or nervous excitement): 9 people, 36.00%
Fever: 7 people, 28.00%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 6 people, 24.00%
Muscle Rigidity (muscle stiffness): 6 people, 24.00%
Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 24.00%
Nausea (feeling of having an urge to vomit): 5 people, 20.00%
Hyperhidrosis (abnormally increased sweating): 5 people, 20.00%
Hypertonia (abnormal increase in muscle tension and a reduced ability of a muscle to stretch): 5 people, 20.00%

What are the existing conditions these people have? *

Suicide Attempt: 1 person, 4.00%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 4.00%
Schizoaffective Disorder (a mental disorder characterized by disordered thought): 1 person, 4.00%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 1 person, 4.00%
Pain: 1 person, 4.00%
Insomnia (sleeplessness): 1 person, 4.00%

* Approximation only. Some reports may have incomplete information.

Do you take Fluoxetine hydrochloride and have Hyperreflexia?

- Check whether Hyperreflexia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluoxetine hydrochloride:

Fluoxetine hydrochloride (13,381 reports)

Hyperreflexia treatments and more:

Hyperreflexia (4,677 reports)

Browse all side effects of Fluoxetine hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperreflexia:

Hyperreflexia (416 drugs)

Browse all the conditions that are associated with Hyperreflexia:

Hyperreflexia (652 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Fluoxetine hydrochloride) and Fluoxetine hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.