Fluoxetine and Abnormal weight gain - a phase IV clinical study of FDA data

Summary:

Abnormal weight gain is reported as a side effect among people who take Fluoxetine (fluoxetine hydrochloride), especially for people who are female, 10-19 old, have been taking the drug for 6 - 12 months also take Lamotrigine, and have Epilepsy.

The phase IV clinical study analyzes which people have Abnormal weight gain when taking Fluoxetine. It is created by eHealthMe based on reports of 94,370 people who have side effects when taking Fluoxetine from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,824 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Abnormal weight gain?

Abnormal weight gain is found to be associated with 257 drugs and 710 conditions by eHealthMe. Check the latest studies of Abnormal weight gain.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

94,370 people reported to have side effects when taking Fluoxetine.
Among them, 62 people (0.07%) have Abnormal weight gain.

Could Fluoxetine cause Abnormal weight gain?

Among these 62 people:

How long have people been on Fluoxetine when they have Abnormal weight gain? *

What is the gender of people who have Abnormal weight gain when taking Fluoxetine? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Abnormal weight gain when taking Fluoxetine? *

What are other drugs people take besides Fluoxetine? *

What are other side effects people have besides Abnormal weight gain? *

Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 15 people, 24.19%
Memory Loss: 14 people, 22.58%
Suicidal Ideation: 14 people, 22.58%
Weight Loss: 10 people, 16.13%
Feeling Abnormal: 10 people, 16.13%
Emotional Disorder: 10 people, 16.13%
Disturbance In Attention: 10 people, 16.13%
Constipation: 10 people, 16.13%
Sleep Disorder: 9 people, 14.52%
Gynecomastia (enlargement of the gland tissue of the male breast): 9 people, 14.52%

What are the existing conditions these people have? *

Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 9 people, 14.52%
Panic Disorder: 8 people, 12.90%
Migraine Without Aura (headache without neurological problems): 8 people, 12.90%
Iron Deficiency Anaemia: 7 people, 11.29%
Psychotic Disorder: 7 people, 11.29%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 7 people, 11.29%
Insomnia (sleeplessness): 7 people, 11.29%
Reactive Attachment Disorder Of Infancy Or Early Childhood (caused by abuse or neglect of an infant's needs for: emotional bonds): 3 people, 4.84%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 3.23%
Bipolar Disorder (mood disorder): 2 people, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Fluoxetine and have Abnormal weight gain?

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Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluoxetine:

Fluoxetine (98,824 reports)

Browse all side effects of Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Abnormal weight gain:

Abnormal weight gain (257 drugs)

Browse all the conditions that are associated with Abnormal weight gain:

Abnormal weight gain (710 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Fluoxetine) and Fluoxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.