Fluoxetine and Sinus node dysfunction - a phase IV clinical study of FDA data

Summary:

Sinus node dysfunction is reported as a side effect among people who take Fluoxetine (fluoxetine hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metformin, and have Back pain.

The phase IV clinical study analyzes which people have Sinus node dysfunction when taking Fluoxetine. It is created by eHealthMe based on reports of 94,370 people who have side effects when taking Fluoxetine from the FDA, and is updated regularly.

What is Fluoxetine?

Fluoxetine has active ingredients of fluoxetine hydrochloride. It is often used in depression. eHealthMe is studying from 98,818 Fluoxetine users. Check the latest studies of Fluoxetine.

What is Sinus node dysfunction?

Sinus node dysfunction (a group of abnormal heart rhythms) is found to be associated with 1,165 drugs and 840 conditions by eHealthMe. Check the latest studies of Sinus node dysfunction.

On Dec, 30, 2025

94,370 people reported to have side effects when taking Fluoxetine.
Among them, 21 people (0.02%) have Sinus node dysfunction.

Could Fluoxetine cause Sinus node dysfunction?

Among these 21 people:

How long have people been on Fluoxetine when they have Sinus node dysfunction? *

What is the gender of people who have Sinus node dysfunction when taking Fluoxetine? *

female: 70 %
male: 30 %

What is the age of people who have Sinus node dysfunction when taking Fluoxetine? *

What are other drugs people take besides Fluoxetine? *

What are other side effects people have besides Sinus node dysfunction? *

Fainting (loss of consciousness and postural tone): 10 people, 47.62%
Bradycardia (abnormally slow heart action): 9 people, 42.86%
Sinus Bradycardia (an unusually slow heartbeat due to heart disease): 8 people, 38.10%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 8 people, 38.10%
Long Qt Syndrome (disorder of the heart's electrical system): 8 people, 38.10%
Headache (pain in head): 6 people, 28.57%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 23.81%
Cardiac Arrest: 5 people, 23.81%
Gastritis (inflammation of stomach): 5 people, 23.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 23.81%

What are the existing conditions these people have? *

Back Pain: 4 people, 19.05%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 3 people, 14.29%
Pain: 1 person, 4.76%
High Blood Pressure: 1 person, 4.76%
Heart Rate Irregular: 1 person, 4.76%
Chest Pain: 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Fluoxetine and have Sinus node dysfunction?

- Check whether Sinus node dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluoxetine:

Fluoxetine (98,818 reports)

Browse all side effects of Fluoxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Sinus node dysfunction:

Sinus node dysfunction (1,165 drugs)

Browse all the conditions that are associated with Sinus node dysfunction:

Sinus node dysfunction (840 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on fluoxetine hydrochloride (the active ingredients of Fluoxetine) and Fluoxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.