Fluticasone propionate and Hyperkeratosis - a phase IV clinical study of FDA data

Summary:

Hyperkeratosis is reported as a side effect among people who take Fluticasone propionate (fluticasone propionate), especially for people who are male, 60+ old, also take Aspirin, and have Psoriasis.

The phase IV clinical study analyzes which people have Hyperkeratosis when taking Fluticasone propionate. It is created by eHealthMe based on reports of 33,984 people who have side effects when taking Fluticasone propionate from the FDA, and is updated regularly.

What is Fluticasone propionate?

Fluticasone propionate has active ingredients of fluticasone propionate. It is often used in allergies. eHealthMe is studying from 35,174 Fluticasone propionate users. Check the latest studies of Fluticasone propionate.

What is Hyperkeratosis?

Hyperkeratosis (thickening of the outer layer of the skin) is found to be associated with 775 drugs and 774 conditions by eHealthMe. Check the latest studies of Hyperkeratosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

33,984 people reported to have side effects when taking Fluticasone propionate.
Among them, 22 people (0.06%) have Hyperkeratosis.

Could Fluticasone propionate cause Hyperkeratosis?

Among these 22 people:

What is the gender of people who have Hyperkeratosis when taking Fluticasone propionate? *

female: 38.1 %
male: 61.9 %

What is the age of people who have Hyperkeratosis when taking Fluticasone propionate? *

What are other drugs people take besides Fluticasone propionate? *

What are other side effects people have besides Hyperkeratosis? *

Itching: 9 people, 40.91%
Stress And Anxiety: 9 people, 40.91%
High Blood Pressure: 9 people, 40.91%
Joint Pain: 7 people, 31.82%
Spinal Osteoarthritis (joint cartilage loss in spine): 6 people, 27.27%
Weakness: 6 people, 27.27%
Pain: 6 people, 27.27%
Hyperlipidaemia (presence of excess lipids in the blood): 5 people, 22.73%
Fall: 5 people, 22.73%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 22.73%

What are the existing conditions these people have? *

Neoplasm Malignant (cancer tumour): 3 people, 13.64%
High Blood Pressure: 3 people, 13.64%
High Blood Cholesterol: 3 people, 13.64%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 13.64%
Osteoporosis (bones weak and more likely to break): 2 people, 9.09%
Lung Neoplasm (tumour of lung): 2 people, 9.09%
Metastases To Spine (cancer spreads to spine): 2 people, 9.09%
Hypersensitivity: 2 people, 9.09%
Calcium Deficiency (lack of calcium): 2 people, 9.09%
Depression: 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Fluticasone propionate and have Hyperkeratosis?

- Check whether Hyperkeratosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fluticasone propionate:

Fluticasone propionate (35,174 reports)

Hyperkeratosis treatments and more:

Hyperkeratosis (8,056 reports)

Browse all side effects of Fluticasone propionate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hyperkeratosis:

Hyperkeratosis (775 drugs)

Browse all the conditions that are associated with Hyperkeratosis:

Hyperkeratosis (774 conditions)

Related publications that referenced our studies

Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .
Lehrer, S., & Rheinstein, P. H. , "Alzheimer’s Disease and Intranasal Fluticasone Propionate in the FDA MedWatch Adverse Events Database", Journal of Alzheimer's disease reports, (Preprint), 1-5., 2018 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on fluticasone propionate (the active ingredients of Fluticasone propionate) and Fluticasone propionate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.