Folate and Toothaches - a phase IV clinical study of FDA data

Summary:

Toothaches is reported as a side effect among people who take Folate (folic acid), especially for people who are male, 30-39 old, also take Flonase, and have Paroxysmal nocturnal haemoglobinuria.

The phase IV clinical study analyzes which people have Toothaches when taking Folate. It is created by eHealthMe based on reports of 5,953 people who have side effects when taking Folate from the FDA, and is updated regularly.

What is Folate?

Folate has active ingredients of folic acid. It is often used in rheumatoid arthritis. eHealthMe is studying from 6,546 Folate users. Check the latest studies of Folate.

What is Toothaches?

Toothaches (tooth pain) is found to be associated with 1,318 drugs and 1,605 conditions by eHealthMe. Check the latest studies of Toothaches.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

5,953 people reported to have side effects when taking Folate.
Among them, 18 people (0.3%) have Toothaches.

Among these 18 people:

What is the gender of people who have Toothaches when taking Folate? *

female: 41.18 %
male: 58.82 %

What is the age of people who have Toothaches when taking Folate? *

What are other drugs people take besides Folate? *

What are other side effects people have besides Toothaches? *

Dyspnea (difficult or laboured breathing): 13 people, 72.22%
Pain: 12 people, 66.67%
Infection: 12 people, 66.67%
Rashes (redness): 12 people, 66.67%
Neuropathy Peripheral (surface nerve damage): 12 people, 66.67%
Constipation: 12 people, 66.67%
Cough: 12 people, 66.67%
Upper Respiratory Tract Infection: 12 people, 66.67%
Oropharyngeal Pain: 12 people, 66.67%
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets): 11 people, 61.11%

What are the existing conditions these people have? *

Paroxysmal Nocturnal Haemoglobinuria (haemoglobin in the urine): 2 people, 11.11%
Pain: 1 person, 5.56%
Light Chain Disease (a rare blood cell disease which is characterized by deposition of fragments of infection-fighting immunoglobulins): 1 person, 5.56%
Infection: 1 person, 5.56%
Hypoglycemia (low blood sugar): 1 person, 5.56%
High Density Lipoprotein Decreased: 1 person, 5.56%
Dyspnea (difficult or laboured breathing): 1 person, 5.56%
Diabetes: 1 person, 5.56%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 1 person, 5.56%
Asthma: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Folate and have Toothaches?

- Check whether Toothaches is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Folate:

Folate (6,546 reports)

Toothaches treatments and more:

Toothaches (28,231 reports)

Browse all side effects of Folate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toothaches:

Toothaches (1,318 drugs)

Browse all the conditions that are associated with Toothaches:

Toothaches (1,605 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on folic acid (the active ingredients of Folate) and Folate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.