Fosamax plus d and Spondylolisthesis - a phase IV clinical study of FDA data

Summary:

Spondylolisthesis is reported as a side effect among people who take Fosamax plus d (alendronate sodium; cholecalciferol), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Fosamax, and have Osteopenia.

The phase IV clinical study analyzes which people have Spondylolisthesis when taking Fosamax plus d. It is created by eHealthMe based on reports of 1,783 people who have side effects when taking Fosamax plus d from the FDA, and is updated regularly.

What is Fosamax plus d?

Fosamax plus d has active ingredients of alendronate sodium; cholecalciferol. It is often used in osteoporosis. eHealthMe is studying from 1,845 Fosamax plus d users. Check the latest studies of Fosamax plus d.

What is Spondylolisthesis?

Spondylolisthesis (displacement of a vertebra or the vertebral column in relation to the vertebrae below) is found to be associated with 566 drugs and 491 conditions by eHealthMe. Check the latest studies of Spondylolisthesis.

On Jul, 17, 2026

1,783 people reported to have side effects when taking Fosamax plus d.
Among them, 63 people (3.53%) have Spondylolisthesis.

Could Fosamax plus d cause Spondylolisthesis?

Among these 63 people:

How long have people been on Fosamax plus d when they have Spondylolisthesis? *

What is the gender of people who have Spondylolisthesis when taking Fosamax plus d? *

female: 92.73 %
male: 7.27 %

What is the age of people who have Spondylolisthesis when taking Fosamax plus d? *

What are other drugs people take besides Fosamax plus d? *

What are other side effects people have besides Spondylolisthesis? *

Femur Fracture: 60 people, 95.24%
Fall: 46 people, 73.02%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 42 people, 66.67%
High Blood Pressure: 31 people, 49.21%
Intervertebral Disc Degeneration (spinal disc degeneration): 31 people, 49.21%
Low Turnover Osteopathy (slow removal of old bone and its replacement by new bone): 30 people, 47.62%
Back Pain: 29 people, 46.03%
Spinal Osteoarthritis (joint cartilage loss in spine): 28 people, 44.44%
Pain In Extremity: 24 people, 38.10%
Intervertebral Disc Protrusion (spinal disc protrusion): 23 people, 36.51%

What are the existing conditions these people have? *

Osteopenia (a condition where bone mineral density is lower than normal): 25 people, 39.68%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 9.52%
High Blood Cholesterol: 6 people, 9.52%
Pain: 5 people, 7.94%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 6.35%
Polyarthritis (arthritis which involves 5 or more joints simultaneously): 3 people, 4.76%
Bone Density Decreased: 3 people, 4.76%
Migraine (headache): 2 people, 3.17%
Depression: 2 people, 3.17%
Hypersensitivity: 2 people, 3.17%

* Approximation only. Some reports may have incomplete information.

Do you take Fosamax plus d and have Spondylolisthesis?

- Check whether Spondylolisthesis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Fosamax plus d:

Fosamax plus d (1,845 reports)

Spondylolisthesis treatments and more:

Spondylolisthesis (3,788 reports)

How severe was Spondylolisthesis and when was it recovered:

Spondylolisthesis in Fosamax plus d

Expand to all the drugs that have ingredients of alendronate sodium; cholecalciferol:

Spondylolisthesis and drugs with ingredients of alendronate sodium; cholecalciferol

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Fosamax plus d:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spondylolisthesis:

Spondylolisthesis (566 drugs)

Browse all the conditions that are associated with Spondylolisthesis:

Spondylolisthesis (491 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on alendronate sodium; cholecalciferol (the active ingredients of Fosamax plus d) and Fosamax plus d (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.